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Cystatin C Predicts Incident Cardiovascular Disease in Twins
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- Arpegard, Johannes (författare)
- Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Emergency Med, Stockholm, Sweden.
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- Magnusson, Patrik K. E. (författare)
- Karolinska Institutet
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- Chen, Xu (författare)
- Karolinska Institutet
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- Ridefelt, Peter (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Pedersen, Nancy L. (författare)
- Karolinska Institutet
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- De Faire, Ulf (författare)
- Karolinska Institutet
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- Svensson, Per (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Med Solna, Stockholm, Sweden;Karolinska Univ Hosp Solna, Dept Emergency Med, Stockholm, Sweden. (creator_code:org_t)
- 2016
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 5:6
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background - Cystatin C is associated with both renal function and atherosclerotic cardiovascular disease (ASCVD). We have previously shown a genetic correlation between cystatin C and prevalent ASCVD. The objective of this article is to study whether variation in cystatin C or creatinine predicts incident ASCVD when controlled for genetic factors.Methods and Results - The predictive value of cystatin C and creatinine for incident ASCVD was studied in 11 402 Swedish twins, free of CVD at baseline, in an adjusted Cox-regression model during a median follow-up of 71 months. Twin pairs discordant for incident stroke, myocardial infarction and ASCVD during follow-up were identified and within-pair comparisons regarding cystatin C and creatinine levels were performed. We also investigated whether contact frequency and degree of shared environment influences were associated with similarity in cystatin C levels. In univariate analysis, cystatin C predicted incident ASCVD hazard ratio 1.57, 95% CI 1.47-1.67. When adjusted for traditional Framingham risk factors as covariates, cystatin C remained a predictor of incident stroke hazard ratio 1.45, 95% CI (1.25-1.70), ASCVD hazard ratio 1.26, 95% CI (1.13-1.41), and myocardial infarction hazard ratio 1.16, 95% CI (1.01-1.33). In twins discordant for incident stroke, cystatin C at baseline was higher in the twin who experienced a stroke compared to the healthy co-twin (1.11 +/- 0.3 mg/L versus 1.06 +/- 0.3 mg/L), whereas creatinine was lower in the twin who developed CVD compared to their healthy co-twins (76.1 +/- 16.9 mu mol/L versus 79.4 +/- 20.3 mu mol/L).Conclusions - Variation in cystatin C relates to incident ASCVD and to stroke when adjusted for genetic confounding. In identical twins, cystatin C may be a sensitive marker of early hypertensive end-organ damage and small-vessel disease, whereas creatinine level may reflect nutritional status. The findings in disease-discordant monozygotic twins indicate that unique, possibly preventable, environmental factors are important.
Nyckelord
- cardiovascular disease
- co-twin-control study
- cystatin C
- genetic epidemiology
- myocardial infarction
- stroke
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)