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Plasma proteomics i...
Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli
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- Söderlund, Stina (författare)
- Uppsala University,Uppsala universitet,Hematologi,Science for Life Laboratory, SciLifeLab,Univ Uppsala Hosp, Sect Hematol, Entrance 50, S-75185 Uppsala, Sweden
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- Christiansson, Lisa (författare)
- Uppsala University,Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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- Persson, Inger (författare)
- Uppsala University,Uppsala universitet,Statistiska institutionen
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- Hjorth-Hansen, Henrik (författare)
- St Olavs Hosp, Dept Hematol, Trondheim, Norway; Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Trondheim, Norway,St. Olav’s University Hospital
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- Richter, Johan (författare)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Simonsson, Bengt (författare)
- Uppsala University,Uppsala universitet,Hematologi
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- Mustjoki, Satu (författare)
- Univ Helsinki, Dept Hematol, Hematol Res Unit Helsinki, Helsinki, Finland; Univ Helsinki, Cent Hosp, Ctr Comprehens Canc, Helsinki, Finland; Univ Helsinki, Dept Clin Chem, Helsinki, Finland,University of Helsinki
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- Olsson-Strömberg, Ulla (författare)
- Uppsala University,Uppsala universitet,Hematologi
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- Loskog, Angelica (författare)
- Uppsala University,Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 50, s. 95-103
- Relaterad länk:
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https://helda.helsin...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND AIMS: The simultaneous measurement of many proteins is now possible using multiplex assays. In this pilot study we investigated a total of 124 proteins in plasma from chronic myeloid leukemia (CML) patients with the purpose of identifying proteins that are differently expressed at diagnosis and after tyrosine kinase inhibitor (TKI) treatment initiation.METHODS: Samples were taken from 14 CML patients at diagnosis and after three months of TKI treatment (imatinib or dasatinib). Samples were analyzed by Mesoscale Discovery, Myriad RBM MAP technology and Olink Proseek.RESULTS: Multiple plasma proteins were differentially expressed before and after initiation of TKI therapy. Protein patterns demonstrated a possible shift towards Th1-immunity and reduced angiogenic stimuli. Further, some plasma proteins were identified that can be of potential interest to study further for biologic, prognostic or therapeutic significance such as E-selectin, uPAR, growth hormone and carbonic anhydrase IX.CONCLUSIONS: Plasma proteomics seems feasible and useful in CML patients, both for studying patterns of protein expression and for identifying single proteins differentially expressed before and after treatment. Plasma proteomics may be useful to map disease activity and biological processes. Hence, plasma proteomics can be used to understand drug mechanisms and treatment responses in CML.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Proteomics
- Chronic myeloid leukemia
- Tyrosine kinase inhibitor
- Th1
- Angiogenesis
- Angiogenesis
- Chronic myeloid leukemia
- Proteomics
- Th1
- Tyrosine kinase inhibitor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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