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Simultaneously elev...
Simultaneously elevated exhaled nitric oxide and serum-eosinophil cationic protein relate to recent asthma events in asthmatics in a cross-sectional population-based study.
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- Mogensen, Ida (författare)
- Uppsala universitet,Lungmedicin och allergologi
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- Alving, Kjell (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Bjerg, A. (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth Clin Paedi, Stockholm, Sweden
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- Borres, Magnus P. (författare)
- Uppsala universitet,Pediatrik
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- Hedlin, G. (författare)
- Karolinska Institutet
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- Sommar, J. (författare)
- Umea Univ, Dept Publ Hlth & Clin Med Occupat Med, Umea, Sweden
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- Dahlén, S-E (författare)
- Karolinska Institutet
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- Janson, Christer (författare)
- Uppsala universitet,Lungmedicin och allergologi
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- Malinovschi, Andrei (författare)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- 2016-09-27
- 2016
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 46:12, s. 1540-1548
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: We have reported that increased fraction of exhaled nitric oxide (FeNO), a measure of TH2 -driven airway inflammation, and blood eosinophil count, a marker of systemic eosinophil inflammation, correlated with asthma attacks in a population-based study.OBJECTIVE: To investigate the relation between simultaneously elevated FeNO and serum eosinophil cationic protein (S-ECP) levels and asthma events among asthmatics.METHODS: Measurements of FeNO (elevated ≥ 25 ppb) and S-ECP (elevated ≥ 20 ng/mL) were performed in 339 adult asthmatics. Asthma events (attacks and symptoms) were self-reported.RESULTS: Simultaneously normal S-ECP and FeNO levels were found in 48% of the subjects. Subjects with simultaneously elevated S-ECP and FeNO (13% of the population) had a higher prevalence of asthma attacks in the preceding 3 months than subjects with normal S-ECP and FeNO (51% vs. 25%, P = 0.001). This was not found for subjects with singly elevated S-ECP (P = 0.14) or FeNO (P = 0.34) levels. Elevated S-ECP and FeNO levels were independently associated with asthma attacks in the preceding 3 months after adjusting for potential confounders (OR (95% CI) 4.2 (2.0-8.8).CONCLUSIONS: Simultaneously elevated FeNO and S-ECP levels were related to a higher likelihood of asthma attacks in the preceding 3 months. This indicates that there is a value in measuring both FeNO and systemic eosinophilic inflammation in patients with asthma to identify individuals at high risk of exacerbations.CLINICAL RELEVANCE: FeNO and S-ECP are markers for inflammation in asthma, but are dependent on different inflammatory pathways and weakly correlated. Simultaneous measurements of both offer better risk characterization of adult asthmatics.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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