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Fronto-facial advan...
Fronto-facial advancement and bipartition in Crouzon-Pfeiffer and Apert syndromes : Impact of fronto-facial surgery upon orbital and airway parameters in FGFR2 syndromes
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- Khonsari, Roman H. (författare)
- Assistance Publique – Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Service de Chirurgie Maxillo-faciale et Plastique, Université Paris-Descartes, Paris, France
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- Way, Benjamin (författare)
- The Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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- Nysjö, Johan (författare)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen för visuell information och interaktion
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- Odri, Guillaume A. (författare)
- Assistance Publique – Hôpitaux de Paris, Hôpital Lariboisière, Service de Chirurgie Orthopédique, Université Paris-Diderot, Paris, France
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- Olszewski, Raphaël (författare)
- Department of Oral and Maxillofacial Surgery, Saint-Luc University Hospital, Catholic University of Leuven, Brussels, Belgium
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- Evans, Robert D. (författare)
- The Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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- Dunaway, David J. (författare)
- The Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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- Nyström, Ingela (författare)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen för visuell information och interaktion
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- Britto, Jonathan A. (författare)
- The Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Journal of Cranio-Maxillofacial Surgery. - : Elsevier BV. - 1010-5182 .- 1878-4119. ; 44:10, s. 1567-1575
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A major concern in FGFR2 craniofaciosynostosis is oculo-orbital disproportion, such that orbital malformation provides poor accommodation and support for the orbital contents and peri-orbita, leading to insufficient eyelid closure, corneal exposure and eventually to functional visual impairment. Fronto-facial monobloc osteotomy followed by distraction osteogenesis aims to correct midfacial growth deficiencies in Crouzon–Pfeiffer syndrome patients. Fronto-facial bipartition osteotomy followed by distraction is a procedure of choice in Apert syndrome patients. These procedures modify the shape and volume of the orbit and tend to correct oculo-orbital disproportion. Little is known about the detailed 3D shape of the orbital phenotype in CPS and AS, and about how this is modified by fronto-facial surgery.Twenty-eight patients with CMS, 13 patients with AS and 40 control patients were included. CT scans were performed before and after fronto-facial surgery. Late post-operative scans were available for the Crouzon–Pfeiffer syndrome group. Orbital morphology was investigated using conventional three-dimensional cephalometry and shape analysis after mesh-based segmentation of the orbital contents.We characterized the 3D morphology of CPS and AS orbits and showed how orbital shape is modified by surgery. We showed that monobloc-distraction in CPS and bipartition-distraction in AS specifically address the morphological characteristics of the two syndromes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Nyckelord
- Monobloc-distraction
- Orbit
- 3D-cephalometry
- Crouzon–Pfeiffer syndrome
- Apert syndrome
- FGFR2
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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