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Diffuse Large B Cel...
Diffuse Large B Cell Lymphoma Cell Line U2946 : Model for MCL1 Inhibitor Testing
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- Quentmeier, Hilmar (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Drexler, Hans G. (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Hauer, Vivien (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- MacLeod, Roderick A. F. (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Pommerenke, Claudia (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Uphoff, Cord C. (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Zaborski, Margarete (författare)
- Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany.
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- Berglund, Mattias (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Univ Uppsala Hosp, Uppsala, Sweden.
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- Enblad, Gunilla (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Univ Uppsala Hosp, Uppsala, Sweden.
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- Amini, Rose-Marie (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany Experimentell och klinisk onkologi (creator_code:org_t)
- 2016-12-01
- 2016
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:12
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma worldwide. We describe the establishment and molecular characteristics of the DLBCL cell line U-2946. This cell line was derived from a 52-year-old male with DLBCL. U-2946 cells carried the chromosomal translocation t(8; 14) and strongly expressed MYC, but not the mature B-cell lymphoma associated oncogenes BCL2 and BCL6. Instead, U-2946 cells expressed the antiapoptotic BCL2 family member MCL1 which was highly amplified genomically (14n). MCL1 amplification is recurrent in DLBCL, especially in the activated B cell (ABC) variant. Results of microarray expression cluster analysis placed U-2946 together with ABC-, but apart from germinal center (GC)-type DLBCL cell lines. The 1q21.3 region including MCL1 was focally coamplified with a short region of 17p11.2 (also present at 14n). The MCL1 inhibitor A-1210477 triggered apoptosis in U-2946 (MCL1(pos)/BCL2(neg)) cells. In contrast to BCL2(pos) DLBCL cell lines, U-2946 did not respond to the BCL2 inhibitor ABT-263. In conclusion, the novel characteristics of cell line U-2946 renders it a unique model system to test the function of small molecule inhibitors, especially when constructing a panel of DLBCL cell lines expressing broad combinations of antiapoptotic BCL2-family members.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Pathology
- Patologi
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- ref (ämneskategori)
- art (ämneskategori)
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Quentmeier, Hilm ...
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Drexler, Hans G.
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Hauer, Vivien
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MacLeod, Roderic ...
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Pommerenke, Clau ...
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Uphoff, Cord C.
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Zaborski, Margar ...
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Berglund, Mattia ...
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Enblad, Gunilla
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Amini, Rose-Mari ...
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Uppsala universitet
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Karolinska Institutet