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Low to moderate lif...
Low to moderate lifetime alcohol consumption is associated with less advanced stages of fibrosis in non-alcoholic fatty liver disease
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- Hagström, Hannes (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Nasr, Patrik, 1987- (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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- Ekstedt, Mattias (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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- Kechagias, Stergios (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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- Önnerhag, Kristina (författare)
- Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden.,Skåne University Hospital, Sweden
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- Nilsson, Emma (författare)
- Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden.,Skåne University Hospital, Sweden
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- Rorsman, Fredrik (författare)
- Uppsala universitet,Gastroenterologi/hepatologi,University of Uppsala Hospital, Sweden
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- Sheikhi, Reza (författare)
- Uppsala universitet,Gastroenterologi/hepatologi,University of Uppsala Hospital, Sweden
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- Marschall, Hanns-Ulrich (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Stål, Per (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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(creator_code:org_t)
- 2016-10-06
- 2017
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 52:2, s. 159-165
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Abstract
Ämnesord
Stäng
- Background and aim: Moderate alcohol consumption has been associated with a lower risk of disease severity in non-alcoholic fatty liver disease (NAFLD). It is unclear if this reflects current or lifetime drinking, or can be attributed to confounders such as diet and exercise. We evaluated the impact of lifetime alcohol consumption on fibrosis severity in NAFLD. Methods: We prospectively enrolled 120 subjects with biopsy-proven NAFLD and through detailed questionnaires examined lifetime alcohol consumption, diet and physical activity. Main outcome measures were odds ratios (OR) for fibrosis stage, calculated through ordinal regression after adjustment for body mass index, diabetes mellitus type 2, smoking and age at biopsy. A biomarker for recent alcohol consumption, phosphatidyl ethanol (PEth) was sampled. Results: An increase in median weekly alcohol consumption to a maximum of 13 drinks per week was associated with lower fibrosis stage (adjusted OR for each incremental unit, 0.86; 95% CI, 0.76-0.97; p = .017). The lowest risk for fibrosis was found with the lowest odds seen in the top quartile of alcohol consumption (aOR 0.23; 95% CI 0.08-0.66; p = .006). Adding soft drink and coffee consumptions, and physical activity to the model did not change the estimates. Subjects with PEth >= 0.3 mu mol/L had higher ORs for a higher fibrosis stage (aOR 2.77; 95% CI 1.01-7.59; p = .047). Conclusion: Lifetime alcohol consumption with up to 13 units per week is associated with lower fibrosis stage in NAFLD. Elevated PEth is associated with higher stages of fibrosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- NAFLD
- NASH
- alcohol
- lifetime alcohol consumption
- fibrosis stage
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Hagström, Hannes
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Nasr, Patrik, 19 ...
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Ekstedt, Mattias
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Kechagias, Sterg ...
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Önnerhag, Kristi ...
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Nilsson, Emma
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visa fler...
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Rorsman, Fredrik
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Sheikhi, Reza
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Marschall, Hanns ...
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Hultcrantz, Rolf
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Stål, Per
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Scandinavian Jou ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet
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Göteborgs universitet