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Five-year outcomes ...
Five-year outcomes in men screened for carotid artery stenosis at 65 years of age : a population-based cohort study
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- Högberg, Dominika (författare)
- Uppsala universitet,Kärlkirurgi,Sahlgrens Univ Hosp, Dept Hybrid & Intervent Surg, S-41345 Gothenburg, Sweden
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- Björck, Martin (författare)
- Uppsala universitet,Kärlkirurgi
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- Mani, Kevin, 1975- (författare)
- Uppsala universitet,Kärlkirurgi
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- Svensjö, Sverker, 1968- (författare)
- Uppsala universitet,Kärlkirurgi,Centrum för klinisk forskning Dalarna
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- Wanhainen, Anders (författare)
- Uppsala universitet,Kärlkirurgi
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 57:6, s. 759-766
- Relaterad länk:
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http://www.ejves.com...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: The aim was to determine the prognosis of 65-year old men five years after carotid ultrasound screening, as well as risk factors for disease progression.Material and methods: All 65-year-old men living in the county of Uppsala 2007-2009 were invited to an ultrasound examination of both carotid arteries and re-invited at age 70. The cohort was grouped into: normal carotids, plaque without significant stenosis, moderate stenosis (50-79%), and severe stenosis (80-99%). The rates of disease progression to death, significant stenosis, and neurological events were assessed, as well as risk factors and medication.Results: Among men participating in carotid screening at age 65, 3057 were re-screened at age 70. In those with normal carotids (n=2318), 23 (1.0%) progressed to a moderate, and four (0.2%) developed a symptomatic severe stenosis. Among those with plaque (n=696), 25 (3.6%) progressed to moderate, and eight (1.1%) to severe stenosis, of whom four (0.6%) had symptoms. Of 31 with 50-79% stenosis, four (12.9%) had progressed to a severe stenosis, of whom two (6.5%) developed symptoms. Five of twelve subjects (42%) with 80-99% stenosis developed symptoms. Disease regression was present among 306 (41.4%) men. In multivariable analysis, smoking, coronary artery disease and hypercholesterolemia were associated with disease progression. The proportions of antiplatelet, statin and antihypertensive treatment in the population at age 70 were 22%, 29% and 55% respectively.Conclusion: Men with plaques and moderate stenosis have a good prognosis, but in those with severe stenosis there was a high risk of neurological events.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- carotid stenosis
- atherosclerotic plaque
- natural history
- mortality
- stroke rate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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