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Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia

Rajala, Hanna L. M. (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland
El Missiry, Mohamed (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland
Ruusila, Anniina (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland
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Koskenvesa, Perttu (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland
Bruemmendorf, Tim H. (författare)
Univ Hosp Aachen RWTH, Internal Med Oncol Hematol & Stem Cell Transplant, Aachen, Germany.,University Hospital Aachen RWTH, Germany
Gjertsen, Bjorn T. (författare)
Univ Bergen, Inst Med, Hematol Sect, Bergen, Norway.,University of Bergen, Norway
Janssen, Jeroen (författare)
Vrije Univ Amsterdam, Dept Hematol, Med Ctr, Amsterdam, Netherlands.,Vrije University of Amsterdam, Netherlands
Lotfi, Kourosh, 1966- (författare)
Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ, Dept Hematol, Linköping, Sweden.;Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden.
Markevarn, Berit (författare)
Univ Bergen, Inst Med, Hematol Sect, Bergen, Norway.,University of Bergen, Norway
Strömberg, Ulla Olsson (författare)
Uppsala universitet,Hematologi,Uppsala University Hospital, Sweden
Stenke, Leif (författare)
Karolinska Institutet,Karolinska Univ Hosp, Div Hematol, Dept Med, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden.
Stentoft, Jesper (författare)
Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.,Aarhus University Hospital, Denmark
Richter, Johan (författare)
Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.,Skåne University Hospital, Sweden
Hjorth-Hansen, Henrik (författare)
St Olavs Hosp, Dept Hematol, Trondheim, Norway.;NTNU, Dept Canc Res & Mol Med, Trondheim, Norway.,St Olavs Hospital, Norway; NTNU, Norway
Kreutzman, Anna (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.;Univ Helsinki, Dept Clin Chem, Helsinki, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland; University of Helsinki, Finland
Mustjoki, Satu (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland.;Univ Helsinki, Dept Clin Chem, Helsinki, Finland.,University of Helsinki, Finland; Helsinki University Hospital, Finland; University of Helsinki, Finland
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Univ Helsinki, Hematol Res Unit Helsinki, Dept Hematol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Ctr Comprehens Canc, Haartmaninkatu 8, Helsinki 00290, Finland. University of Helsinki, Finland; Helsinki University Hospital, Finland (creator_code:org_t)
2017-03-23
2017
Engelska.
Ingår i: Journal of Cancer Research and Clinical Oncology. - : SPRINGER. - 0171-5216 .- 1432-1335. ; 143:8, s. 1543-1554
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Purpose Tyrosine kinase inhibitors (TKIs) have well-characterized immunomodulatory effects on T and NK cells, but the effects on the humoral immunity are less well known. In this project, we studied TKI-induced changes in B cell-mediated immunity. Methods We collected peripheral blood (PB) and bone marrow (BM) samples from chronic myeloid leukemia (CML) patients before and during first-line imatinib (n = 20), dasatinib (n = 16), nilotinib (n = 8), and bosutinib (n = 12) treatment. Plasma immunoglobulin levels were measured, and different B cell populations in PB and BM were analyzed with flow cytometry. Results Imatinib treatment decreased plasma IgA and IgG levels, while dasatinib reduced IgM levels. At diagnosis, the proportion of patients with IgA, IgG, and IgM levels below the lower limit of normal (LLN) was 0, 11, and 6% of all CML patients, respectively, whereas at 12 months timepoint the proportions were 6% (p = 0.13), 31% (p = 0.042) and 28% (p = 0.0078). Lower initial Ig levels predisposed to the development of hypogammaglobulinemia during TKI therapy. Decreased Ig levels in imatinibtreated patients were associated with higher percentages of immature BM B cells. The patients, who had low Ig levels during the TKI therapy, had significantly more frequent minor infections during the follow-up compared with the patients with normal Ig values (33% vs. 3%, p = 0.0016). No severe infections were reported, except recurrent upper respiratory tract infections in one imatinib-treated patient, who developed severe hypogammaglobulinemia. Conclusions TKI treatment decreases plasma Ig levels, which should be measured in patients with recurrent infections.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

CML
Tyrosine kinase inhibitor
B cell
Immunoglobulin

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