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A non-fatal intoxic...
A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP
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- Johansson, Anna (författare)
- Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden.,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Lindstedt, Daniel (författare)
- Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden.,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Roman, Markus (författare)
- Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden.,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Thelander, Gunilla (författare)
- Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden.,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Nielsen, Elisabet I., 1973- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Sweden
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- Lennborn, Ulrica (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala University, Sweden
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- Sandler, Håkan (författare)
- Uppsala universitet,Rättsmedicin,Natl Board Forens Med, Dept Forens Med, Uppsala, Sweden,National Board Forens Med, Sweden; Uppsala University, Sweden
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- Rubertsson, Sten (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala University, Sweden
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- Ahlner, Johan (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Kronstrand, Robert (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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- Kugelberg, Fredrik (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden
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Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden (creator_code:org_t)
- ELSEVIER IRELAND LTD, 2017
- 2017
- Engelska.
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Ingår i: Forensic Science International. - : ELSEVIER IRELAND LTD. - 0379-0738 .- 1872-6283. ; 275, s. 76-82
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Introduction: 3-methoxyphencyclidine (3-MeO-PCP) appeared on the illicit drug market in 2011 and is an analogue of phencyclidine, which exhibits anesthetic, analgesic and hallucinogenic properties. In this paper, we report data from a non-fatal intoxication and seven deaths involving 3-MeO-PCP in Sweden during the period March 2014 until June 2016. Case descriptions: The non-fatal intoxication case, a 19-year-old male with drug problems and a medical history of depression, was found awake but tachycardic, hypertensive, tachypnoeic and catatonic at home. After being hospitalized, his condition worsened as he developed a fever and lactic acidosis concomitant with psychomotor agitation and hallucinations. After 22 h of intensive care, the patient had made a complete recovery. During his hospitalization, a total of four blood samples were collected at different time points. The seven autopsy cases, six males and one female, were all in their twenties to thirties with psychiatric problems and/or an ongoing drug abuse. Methods: 3-MeO-PCP was identified with liquid chromatography (LC)/time-of-flight technology and quantified using LC-tandem mass spectrometry. Results: In the clinical case, the concentration of 3-MeO-PCP was 0.14 mu g/g at admission, 0.08 mu g/g 2.5 h after admission, 0.06 mu g/g 5 h after admission and 0.04 mu g/g 17 h after admission. The half-life of 3-MeO-PCP was estimated to 11 h. In the autopsy cases, femoral blood concentrations ranged from 0.05 mu g/g to 0.38 mu g/g. 3-MeO-PCP was the sole finding in the case with the highest concentration and the cause of death was established as intoxication with 3-MeO-PCP. In the remaining six autopsy cases, other medications and drugs of abuse were present as well. Conclusion: Despite being scheduled in January 2015, 3-MeO-PCP continues to be abused in Sweden. Exposure to 3-MeO-PCP may cause severe adverse events and even death, especially if the user does not receive life-supporting treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Rättsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Forensic Science (hsv//eng)
Nyckelord
- Dissociative drugs
- Phencyclidine
- 3-MeO-PCP
- Intoxication
- Postmortem blood concentrations
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Johansson, Anna
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Lindstedt, Danie ...
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Roman, Markus
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Thelander, Gunil ...
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Nielsen, Elisabe ...
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Lennborn, Ulrica
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Sandler, Håkan
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Rubertsson, Sten
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Ahlner, Johan
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Kronstrand, Robe ...
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Kugelberg, Fredr ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Rättsmedicin
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Forensic Science ...
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Uppsala universitet
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Linköpings universitet