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NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons

Senn, Pascal (författare)
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland.;Univ Hosp Geneva, Dept Clin Neurosci, Serv ORL & HNS, HUG, Geneva, Switzerland.
Roccio, Marta (författare)
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland.
Hahnewald, Stefan (författare)
Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland.
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Frick, Claudia (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
Kwiatkowska, Monika (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
Ishikawa, Masaaki (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
Bako, Peter (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
Li, Hao, 1984- (författare)
Uppsala universitet,Öron-, näs- och halssjukdomar
Edin, Fredrik, 1985- (författare)
Uppsala universitet,Öron-, näs- och halssjukdomar
Liu, Wei (författare)
Uppsala universitet,Öron-, näs- och halssjukdomar
Rask-Andersen, Helge (författare)
Uppsala universitet,Öron-, näs- och halssjukdomar
Pyykko, Ilmari (författare)
Univ Tampere, Hearing & Balance Res Unit, Dept Otorhinolaryngol, Tampere, Finland.;Univ Tampere, Finnish Ctr Alternat Methods, Tampere, Finland.
Zou, Jing (författare)
Univ Tampere, Hearing & Balance Res Unit, Dept Otorhinolaryngol, Tampere, Finland.;Univ Tampere, Finnish Ctr Alternat Methods, Tampere, Finland.
Mannerstrom, Marika (författare)
Univ Tampere, Hearing & Balance Res Unit, Dept Otorhinolaryngol, Tampere, Finland.;Univ Tampere, Finnish Ctr Alternat Methods, Tampere, Finland.
Keppner, Herbert (författare)
HES SO Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, La Chaux De Fonds, Switzerland.
Homsy, Alexandra (författare)
HES SO Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, La Chaux De Fonds, Switzerland.
Laux, Edith (författare)
HES SO Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, La Chaux De Fonds, Switzerland.
Llera, Miguel (författare)
HES SO Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, La Chaux De Fonds, Switzerland.
Lellouche, Jean-Paul (författare)
Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel.
Ostrovsky, Stella (författare)
Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel.
Banin, Ehud (författare)
Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel.
Gedanken, Aharon (författare)
Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel.
Perkas, Nina (författare)
Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, Ramat Gan, Israel.;Bar Ilan Univ, Dept Chem, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel.
Wank, Ute (författare)
EMC Microcollect GmbH, Tubingen, Germany.
Wiesmueller, Karl-Heinz (författare)
EMC Microcollect GmbH, Tubingen, Germany.
Mistrik, Pavel (författare)
MED EL GmbH, Worldwide Headquarters, Innsbruck, Austria.
Benav, Heval (författare)
MED EL GmbH, Worldwide Headquarters, Innsbruck, Austria.
Garnham, Carolyn (författare)
MED EL GmbH, Worldwide Headquarters, Innsbruck, Austria.
Jolly, Claude (författare)
MED EL GmbH, Worldwide Headquarters, Innsbruck, Austria.
Gander, Filippo (författare)
SCIPROM Sarl, Rue Ctr 70, St Sulpice, Switzerland.
Ulrich, Peter (författare)
SCIPROM Sarl, Rue Ctr 70, St Sulpice, Switzerland.
Mueller, Marcus (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
Loewenheim, Hubert (författare)
Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen, Germany.
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Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland;Univ Bern, Dept Clin Res, Bern, Switzerland.;Univ Hosp Geneva, Dept Clin Neurosci, Serv ORL & HNS, HUG, Geneva, Switzerland. Univ Bern, Inselspital, Univ Dept ORL Head & Neck Surg, Bern, Switzerland.;Univ Bern, Dept Clin Res, Bern, Switzerland. (creator_code:org_t)
2017
2017
Engelska.
Ingår i: Otology and Neurotology. - 1531-7129 .- 1537-4505. ; 38:8, s. E224-E231
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence suboptimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intra-cochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)

Nyckelord

Auditory nerve regeneration
BDNF
Cochlear implant
Gapless interface
Guinea pig
Hearing loss
Hydrogel
Multi-electrode array
Neuron-electrode interface

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