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Osteoinduction by F...
Osteoinduction by Foamed and 3D-Printed Calcium Phosphate Scaffolds : Effect of Nanostructure and Pore Architecture
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- Barba, Albert (författare)
- Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politecnica de Catalunya
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- Diez-Escudero, Anna (författare)
- Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politecnica de Catalunya
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- Maazouz, Yassine (författare)
- Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politecnica de Catalunya
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- Rappe, Katrin (författare)
- Bone Healing Group, Small Animal Surgery Department, Veterinary School, Universitat Autonoma de Barcelona
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- Espanol, Montserrat (författare)
- Barcelona Research Center in Multiscale Science and Engineering, Universitat Politecnica de Catalunya
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- Montufar, Edgar B (författare)
- Barcelona Research Center in Multiscale Science and Engineering, Universitat Politecnica de Catalunya
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- Bonany, Mar (författare)
- Barcelona Research Center in Multiscale Science and Engineering, Universitat Politecnica de Catalunya
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- Sadowska, Joanna M (författare)
- Barcelona Research Center in Multiscale Science and Engineering, Universitat Politecnica de Catalunya
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- Guillem-Marti, Jordi (författare)
- Barcelona Research Center in Multiscale Science and Engineering, Universitat Politecnica de Catalunya
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- Öhman, Caroline (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine
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- Persson, Cecilia (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine
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- Manzanares, Maria-Cristina (författare)
- Human Anatomy and Embryology Unit, Department of Pathology and Experimental Therapeutics, Universitat de Barcelona
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- Franch, Jordi (författare)
- Bone Healing Group, Small Animal Surgery Department, Veterinary School, Universitat Autonoma de Barcelona
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- Ginebra, Maria-Pau (författare)
- Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politecnica de Catalunya
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(creator_code:org_t)
- 2017-11-20
- 2017
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 9:48, s. 41722-41736
- Relaterad länk:
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https://upcommons.up...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still unclear, microporosity and specific surface area (SSA) have been identified as critical factors in material-associated osteoinduction. However, only sintered ceramics, which have a limited range of porosities and SSA, have been analyzed so far. In this work, we were able to extend these ranges to the nanoscale, through the foaming and 3D-printing of biomimetic calcium phosphates, thereby obtaining scaffolds with controlled micro- and nanoporosity and with tailored macropore architectures. Calcium-deficient hydroxyapatite (CDHA) scaffolds were evaluated after 6 and 12 weeks in an ectopic-implantation canine model and compared with two sintered ceramics, biphasic calcium phosphate and β-tricalcium phosphate. Only foams with spherical, concave macropores and not 3Dprinted scaffolds with convex, prismatic macropores induced significant ectopic bone formation. Among them, biomimetic nanostructured CDHA produced the highest incidence of ectopic bone and accelerated bone formation when compared with conventional microstructured sintered calcium phosphates with the same macropore architecture. Moreover, they exhibited different bone formation patterns; in CDHA foams, the new ectopic bone progressively replaced the scaffold, whereas in sintered biphasic calcium phosphate scaffolds, bone was deposited on the surface of the material, progressively filling the pore space. In conclusion, this study demonstrates that the high reactivity of nanostructured biomimetic CDHA combined with a spherical, concave macroporosity allows the pushing of the osteoinduction potential beyond the limits of microstructured calcium phosphate ceramics.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- osteoinduction
- 3D-printing
- foaming
- nanostructure
- calcium phosphate
- Teknisk fysik med inriktning mot materialvetenskap
- Engineering Science with specialization in Materials Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Barba, Albert
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Diez-Escudero, A ...
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Maazouz, Yassine
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Rappe, Katrin
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Espanol, Montser ...
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Montufar, Edgar ...
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visa fler...
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Bonany, Mar
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Sadowska, Joanna ...
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Guillem-Marti, J ...
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Öhman, Caroline
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Persson, Cecilia
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Manzanares, Mari ...
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Franch, Jordi
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Ginebra, Maria-P ...
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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ACS Applied Mate ...
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Uppsala universitet