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Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis : a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Burman, Joachim, 1974- (author)
Uppsala universitet,Neurologi
Kirgizov, K (author)
Russian Childrens Res Hosp, BMT Dept, Moscow, Russia
Carlson, Kristina (author)
Uppsala universitet,Hematologi
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Badoglio, M (author)
Hop St Antoine, EBMT Paris Study Off, Paris, France
Mancardi, G L (author)
Univ Genoa, Dept Neurosci, Genoa, Italy
De Luca, G (author)
Univ G dAnnunzio, Multiple Sclerosis Ctr, Neurol Clin, Chieti, Italy
Casanova, B (author)
Hosp Univ & Politecninc La Fe, Neuroimmunol Unit, Valencia, Spain
Ouyang, J (author)
Nanjing Univ, Dept Hematol, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Jiangsu, Peoples R China
Bembeeva, R (author)
Pirogov Russian Natl Res Med Univ, Neurosurg & Genet Pediat Fac, Dept Neurol, Moscow, Russia
Haas, J (author)
Jud Krankenhaus, Berlin, Germany
Bader, P (author)
GW Goethe Univ Hosp, Dept Children & Adolescents, Div Stem Cell Transplantat & Immunol, Frankfurt, Germany
Snowden, J (author)
Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, S Yorkshire, England; Univ Sheffield, Sheffield, S Yorkshire, England
Farge, D (author)
Paris 7 Univ, INSERM U1160, Paris, France; Paris7 Denis Diderot Univ, St Louis Hosp, AP HP,UF 04, Unite Med Interne Malad Autoimmunes & Pathol Vasc, Paris, France
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 (creator_code:org_t)
2017-03-20
2017
English.
In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 52:8, s. 1133-1137
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Autologous hematopoietic stem cell transplantation (aHSCT) is a promising therapy for multiple sclerosis (MS), which has mainly been used in adults. The purpose of this study was to investigate efficacy and adverse events of aHSCT in the treatment of children with MS using data from the European Society for Blood and Marrow Transplantation registry. Twenty-one patients with a median follow-up time of 2.8 years could be identified. PFS at 3 years was 100%, 16 patients improved in expanded disability status scale score and only 2 patients experienced a clinical relapse. The procedure was generally well tolerated and only two instances of severe transplant-related toxicity were recorded. There was no treatment-related mortality, although one patient needed intensive care. aHSCT may be a therapeutic option for children with disease that does not respond to standard care.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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