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GDF-15 and TRAIL-R2...
GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction
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- Skau, Emma (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för medicinska vetenskaper,Hosp Vastmanland, Dept Clin Physiol, SE-72189 Vasteras, Sweden
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- Henriksen, Egil (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Hosp Vastmanland, Dept Clin Physiol, SE-72189 Vasteras, Sweden
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- Wagner, Philippe (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Hedberg, Pär (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Hosp Vastmanland, Dept Clin Physiol, SE-72189 Vasteras, Sweden
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- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi
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- Leppert, Jerzy (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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(creator_code:org_t)
- 2017-08
- 2017
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 24:15, s. 1576-1583
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background The Proximity Extension Assay proteomics chip provides a large-scale analysis of 92 biomarkers linked to cardiovascular disease or inflammation. We aimed to identify the biomarkers that best predicted long-term all-cause mortality in patients with acute myocardial infarction. Methods In this prospective cohort study, 92 biomarkers were analysed in 847 consecutive patients from the Vastmanland Myocardial Infarction Study with a median follow-up of 6.9 years. Results The mean ( standard deviation) age of the patients was 70 (11.8) years and 32.7% were female. Two hundred and seven patients had died after follow-up. The biomarkers most strongly linked to all-cause mortality were growth differentiation factor 15 (GDF-15) and tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2). Cox regression analysis showed that GDF-15 (hazard ratio 1.25 per unit change, 95% confidence interval, 1.02-1.53, p=0.031) and TRAIL-R2 (hazard ratio 1.37 per unit change, 95% confidence interval 1.12-1.67, p=0.002) were independent predictors of long-term all-cause mortality after adjusting for age, gender, diabetes, previous myocardial infarction, stroke, heart failure, hypertension, smoking, hypercholesterolaemia, body mass index, ST-elevation myocardial infarction, left ventricular ejection fraction, troponin I, estimated glomerular filtration rate, N-terminal pro-brain natriuretic peptide and C-reactive protein. The combination of GDF-15 and TRAIL-R2 with established risk factors and biomarkers showed a discriminating accuracy of separating survivors from non-survivors with a cross-validated area under the receiving operating characteristics curve of 0.88 within five years. Conclusion GDF-15 and TRAIL-R2 were the most powerful Proximity Extension Assay chip biomarkers in predicting long-term all-cause mortality in patients with acute myocardial infarction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Myocardial infarction
- biomarkers
- mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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