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Development of a cl...
Development of a clinically feasible [11C]PE2I PET method for differential diagnosis of parkinsonism using reduced scan duration and automated reference region extraction.
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- Jonasson, My (författare)
- Uppsala universitet,Radiologi
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- Appel, Lieuwe (författare)
- Uppsala universitet,Radiologi
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- Danfors, Torsten (författare)
- Uppsala universitet,Radiologi
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- Nyholm, Dag (författare)
- Uppsala universitet,Neurologi
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- Askmark, Håkan (författare)
- Uppsala universitet,Neurologi
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- Frick, Andreas (författare)
- Uppsala universitet,Institutionen för psykologi
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- Engman, Jonas (författare)
- Uppsala universitet,Institutionen för psykologi
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: American Journal of Nuclear Medicine and Molecular Imaging. - 2160-8407. ; 7:6, s. 263-274
- Relaterad länk:
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https://www.ncbi.nlm...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- [11C]PE2I is a highly selective dopamine transporter PET ligand. Parametric images based on dynamic [11C]PE2I scans, showing dopamine transporter availability (BPND) and relative cerebral blood flow (R1), can be used in differential diagnosis of parkinsonism. This work aimed to investigate a shortened scan duration and automated generation of parametric images which are two prerequisites for routine clinical application. Twelve subjects with parkinsonism and seventeen healthy controls underwent 80 min dynamic [11C]PE2I PET scans. BPND and R1 images were generated using cerebellum reference region defined on a co-registered MRI, as well as a supervised cluster analysis (SVCA)-based reference. Initial 20, 30 and 40 min of the scans were extracted and images of standardized uptake value ratio (SUVR) and R1 were computed using MRI- and SVCA-based reference. Correlation was high between striatal 80 min MRI-based BPND and 40 min SVCA-based SUVR-1 (R2=0.95). High correlation was also found between R1 values in striatal and limbic regions (R2≥0.91) whereas correlation was moderate for cortical regions (R2=0.71). The results indicate that dynamic [11C]PE2I scans can be restricted to 40 min and that SVCA can be used for automatic extraction of a reference region. These outcomes will support routine applications of [11C]PE2I PET in clinical settings.
Nyckelord
- PET
- [11C]PE2I
- parametric images
- parkinsonism
- supervised clustering
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jonasson, My
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Appel, Lieuwe
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Danfors, Torsten
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Nyholm, Dag
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Askmark, Håkan
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Frick, Andreas
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visa fler...
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Engman, Jonas
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Furmark, Tomas
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Sörensen, Jens
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Lubberink, Mark
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visa färre...
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Uppsala universitet