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The environmental n...
The environmental neurotoxin β-N-methylamino-l-alanine (l-BMAA) is deposited into birds' eggs
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- Andersson, Marie, 1974- (författare)
- Uppsala universitet,Miljötoxikologi
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- Karlsson, Oskar (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Brandt, Ingvar (författare)
- Uppsala universitet,Miljötoxikologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier BV. - 0147-6513 .- 1090-2414. ; 147, s. 720-724
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- C-carboxyl-labeled BMAA were compared. The results revealed a pronounced incorporation of radioactivity in the eggs, predominantly in the yolk but also in the albumen. Imaging analysis showed that the concentrations of radioactivity in the liver decreased about seven times between the 24h and the 72h time points, while the concentrations in egg yolk remained largely unchanged. At 72h the egg yolk contained about five times the concentration of radioactivity in the liver. Both BMAA preparations gave rise to similar distribution pattern in the bird tissues and in the eggs, indicating metabolic stability of the labeled groups. The demonstrated deposition into eggs warrants studies of BMAAs effects on bird development. Moreover, birds' eggs may be a source of human BMAA exposure, provided that the laying birds are exposed to BMAA via their diet.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Birds' eggs
- Cyanobacterial neurotoxin
- Developmental toxicity
- Human exposure
- Secretion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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