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Role of peroxisome ...
Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue : assessment of adipogenesis and adipocyte glucose and lipid turnover.
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- Kamble, Prasad G. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Pereira, Maria J, 1981- (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Gustafsson, Stefan (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Lundkvist, Per (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Castillejo-Lopez, Casimiro (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Ingelsson, Erik, 1975- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Eriksson, Jan W. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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(creator_code:org_t)
- 2018-08-14
- 2018
- Engelska.
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Ingår i: Adipocyte. - : Informa UK Limited. - 2162-3945 .- 2162-397X. ; 7:4, s. 285-296
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained adipose tissue (AT) before and 3 h after oral glucose (OGTT) in carriers and non-carriers of the Ala allele (12 Pro/Pro, 15 Pro/Ala, and 13 Ala/Ala). Adipogenesis, adipocyte glucose uptake and lipolysis as well as PPARγ target genes expression were investigated and compared between the genotype groups. On fasting and post-OGTT, neither basal nor insulin-stimulated adipocyte glucose uptake differed between genotypes. Compared to fasting, a decreased hormone-sensitive lipase gene expression in Pro/Pro (p<0.05) also accompanied with a higher antilipolytic effect of insulin post-OGTT (p<0.01). The adipocyte size was similar across groups. Preadipocyte differentiation rates between Pro/Pro and Ala/Ala were unchanged. In conclusion, no major differences in AT differentiation, glucose uptake, lipolysis or expression of PPARγ target genes were observed between different PPARγ Pro12Ala genotypes. Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
Nyckelord
- PPARG Pro12Ala
- human adipose tissue
- metabolism and adipogenesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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