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Cannabinoid Type 1 ...
Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue
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- Lahesmaa, Minna (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Turku PET Ctr, Turku, Finland
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- Eriksson, Olof (författare)
- Uppsala universitet,Theranostics,Abo Akad Univ, Turku PET Ctr, Turku, Finland
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- Gnad, Thorsten (författare)
- Univ Bonn, Inst Pharmacol & Toxicol, Bonn, Germany
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- Oikonen, Vesa (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland
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- Bucci, Marco (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland
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- Hirvonen, Jussi (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Univ Turku, Dept Radiol, Turku, Finland
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- Koskensalo, Kalle (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Turku PET Ctr, Turku, Finland
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- Teuho, Jarmo (författare)
- Turku Univ Hosp, Turku PET Ctr, Turku, Finland
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- Niemi, Tarja (författare)
- Turku Univ Hosp, Dept Plast & Gen Surg, Turku, Finland
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- Taittonen, Markku (författare)
- Turku Univ Hosp, Dept Anesthesiol, Turku, Finland
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- Lahdenpohja, Salla (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland
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- Din, Mueez U. (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland
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- Haaparanta-Solin, Merja (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Univ Turku, Med Res Labs, Turku, Finland
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- Pfeifer, Alexander (författare)
- Univ Bonn, Inst Pharmacol & Toxicol, Bonn, Germany
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- Virtanen, Kirsi A. (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Turku PET Ctr, Turku, Finland
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- Nuutila, Pirjo (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Dept Endocrinol, Turku, Finland
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(creator_code:org_t)
- 2018-04-12
- 2018
- Engelska.
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Ingår i: Diabetes. - : AMER DIABETES ASSOC. - 0012-1797 .- 1939-327X. ; 67:7, s. 1226-1236
- Relaterad länk:
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https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Activating brown adipose tissue (BAT) could provide a potential approach for the treatment of obesity and metabolic disease in humans. Obesity is associated with upregulation of the endocannabinoid system, and blocking the cannabinoid type 1 receptor (CB1R) has been shown to cause weight loss and to decrease cardiometabolic risk factors. These effects may be mediated partly via increased BAT metabolism, since there is evidence that CB1R antagonism activates BAT in rodents. To investigate the significance of CB1R in BAT function, we quantified the density of CB1R in human and rodent BAT using the positron emission tomography radioligand [F-18]FMPEP-d(2) and measured BAT activation in parallel with the glucose analog [F-18]fluorodeoxyglucose. Activation by cold exposure markedly increased CB1R density and glucose uptake in the BAT of lean men. Similarly, 3-receptor agonism increased CB1R density in the BAT of rats. In contrast, overweight men with reduced BAT activity exhibited decreased CB1R in BAT, reflecting impaired endocannabinoid regulation. Image-guided biopsies confirmed CB1R mRNA expression in human BAT. Furthermore, CB1R blockade increased glucose uptake and lipolysis of brown adipocytes. Our results highlight that CB1Rs are significant for human BAT activity, and the CB1Rs provide a novel therapeutic target for BAT activation in humans.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Diabetes
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- Av författaren/redakt...
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Lahesmaa, Minna
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Eriksson, Olof
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Gnad, Thorsten
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Oikonen, Vesa
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Bucci, Marco
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Hirvonen, Jussi
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Koskensalo, Kall ...
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Teuho, Jarmo
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Niemi, Tarja
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Taittonen, Markk ...
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Lahdenpohja, Sal ...
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Din, Mueez U.
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Haaparanta-Solin ...
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Pfeifer, Alexand ...
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Virtanen, Kirsi ...
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Nuutila, Pirjo
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetes
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Uppsala universitet