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Comparing osteonecr...
Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia
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- Mogensen, Signe Sloth (författare)
- Rigshosp, Univ Hosp, Juliane Marie Ctr, Dept Pediat & Adolescent Med, JMC 5704,Blegdamsvej 9, DK-2100 Copenhagen, Denmark
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- Harila-Saari, Arja (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden
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- Makitie, Outi (författare)
- Karolinska Institutet
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- Myrberg, Ida Hed (författare)
- Karolinska Institutet
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- Niinimaki, Riitta (författare)
- Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland;Univ Oulu, PEDEGO Res Unit, Oulu, Finland
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- Vestli, Anne (författare)
- Oslo Univ Hosp, Div Pediat & Adolescent Med, Dept Pediat Oncol & Hematol, Oslo, Norway
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- Hafsteinsdottir, Solveig (författare)
- Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland
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- Griskevicius, Laimonas (författare)
- Vilnius Univ, Fac Med, Vilnius, Lithuania;Vilnius Univ Hosp Santariskiu Klinikos, Transfus Med Ctr, Vilnius, Lithuania;Vilnius Univ Hosp Santariskiu Klinikos, Dept Hematol, Oncol, Vilnius, Lithuania
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- Saks, Kadri (författare)
- Tallinn Childrens Hosp, Dept Hematol Oncol, Tallinn, Estonia
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- Hallböök, Helene (författare)
- Uppsala universitet,Hematologi,Uppsala Univ, Dept Med Sci, Uppsala, Sweden
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- Retpen, Jens (författare)
- Univ Hosp Herlev Gentofte, Dept Orthoped Surg, Copenhagen, Denmark
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- Helt, Louise Rold (författare)
- Rigshosp, Univ Hosp, Juliane Marie Ctr, Dept Pediat & Adolescent Med, JMC 5704,Blegdamsvej 9, DK-2100 Copenhagen, Denmark
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- Toft, Nina (författare)
- Rigshosp, Univ Hosp, Dept Hematol, Copenhagen, Denmark
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- Schmiegelow, Kjeld (författare)
- Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark;Rigshosp, Univ Hosp, Juliane Marie Ctr, Dept Pediat & Adolescent Med, JMC 5704,Blegdamsvej 9, DK-2100 Copenhagen, Denmark
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- Frandsen, Thomas Leth (författare)
- Rigshosp, Univ Hosp, Juliane Marie Ctr, Dept Pediat & Adolescent Med, JMC 5704,Blegdamsvej 9, DK-2100 Copenhagen, Denmark
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(creator_code:org_t)
- 2018-06-26
- 2018
- Engelska.
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Ingår i: Pediatric Blood & Cancer. - : WILEY. - 1545-5009 .- 1545-5017. ; 65:10
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Treatment-related osteonecrosis (ON) is a serious complication of treatment of acute lymphoblastic leukemia (ALL).Procedure: This study included 1,489 patients with ALL, aged 1-45years, treated according to the Nordic Society of Paediatric Haematology and Oncology ALL2008 protocol, using alternate-week dexamethasone during delayed intensification, with prospective registration of symptomatic ON. We aimed at comparing risk factors, timing, and clinical characteristics of ON in children and young adults.Results: ON was diagnosed in 67 patients, yielding a 5-year cumulative incidence of 6.3%, but 28% in female adolescents. Median age at ALL diagnosis was 12.1years and 14.9years for females and males, respectively. At ON diagnosis, 59 patients had bone pain (91%) and 30 (46%) had multiple-joint involvement. The median interval between ALL and ON diagnosis was significantly shorter in children aged 1.0-9.9years (0.7years [range: 0.2-2.1]) compared with adolescents (1.8years [range: 0.3-3.7, P<0.001]) and adults (2.1years [range: 0.4-5.3, P=0.001]). Female sex was a risk factor in adolescent patients (hazard ratio [HR]=2.1, 95% confidence interval [CI]: 1.1-4.2) but not in children aged 1.1-9.9years (HR=2.4, 95% CI: 0.9-6.2, P=0.08) or adults aged 19-45years (HR=1.1, 95% CI: 0.3-4.0). Age above 10years at ALL diagnosis (odds ratio [OR]=3.7, P=0.026) and multiple joints affected at ON diagnosis (OR=3.4, P=0.027) were risk factors for developing severe ON.Conclusion: We provide a detailed phenotype of patients with ALL with symptomatic ON, including description of risk factors and timing of ON across age groups. This awareness is essential in exploring measures to prevent development of ON.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- acute lymphoblastic leukemia
- osteonecrosis
- phenotype
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mogensen, Signe ...
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Harila-Saari, Ar ...
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Makitie, Outi
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Myrberg, Ida Hed
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Niinimaki, Riitt ...
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Vestli, Anne
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visa fler...
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Hafsteinsdottir, ...
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Griskevicius, La ...
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Saks, Kadri
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Hallböök, Helene
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Retpen, Jens
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Helt, Louise Rol ...
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Toft, Nina
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Schmiegelow, Kje ...
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Frandsen, Thomas ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Pediatric Blood ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet