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Z-score maps from l...
Z-score maps from low-dose 18F-FDG PET of the brain in neurodegenerative dementia.
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- Fällmar, David (författare)
- Uppsala universitet,Radiologi
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- Lilja, Johan (författare)
- Uppsala universitet,Radiologi
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- Danfors, Torsten, 1964- (författare)
- Uppsala universitet,Radiologi
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visa fler...
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- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
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Iyer, Victor (författare)
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi
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visa färre...
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: American Journal of Nuclear Medicine and Molecular Imaging. - 2160-8407. ; 8:4, s. 239-246
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Neuroimaging is a central part of diagnostic work-up of patients with suspected neurodegenerative disease. FDG-PET can reveal pathological changes earlier and more reliably than morphological imaging. Diagnostic accuracy can be improved by constructing 3D SSP Z-score maps, showing patterns of significant deficits. During FDG-PET, the subject receives a moderate but not insignificant dose of ionizing radiation, and a dose reduction with retained image quality is desirable. With lower dose, repeated examinations can become a useful tool for monitoring disease progress and potential effects of disease-modifying interventions. The aim of this study was to evaluate Z-maps created from low-dose and normal-dose FDG-PET of the brain, with quantitative and qualitative methods. Nine patients with neurodegenerative disorders were prospectively enrolled and nine age-matched controls were recruited through advertising. All subjects (n=18) underwent two FDG-PET scans on separate occasions; a routine and a low-dose scan. The routine dosage of FDG was 3 MBq/kg, and low dosage was 0.75 MBq/kg. 3D-SSP images showing Z-scores of < -1.96 were created from 10-minute summations. The study was comprised of a quantitative part comparing the Z-scores, and a qualitative part where experienced nuclear medicine specialists visually assessed the images. Regarding the quantitative part, Bland-Altman analysis showed a slight constant bias (0.206). Regarding qualitative discrimination between patients and controls, the performance between normal- and low-dose were equal, both showing 72% sensitivity, 83% specificity and 78% accuracy. In this study, visual assessment of 3D-SSP Z-score maps from low-dose FDG-PET provided diagnostic information highly comparable to normal-dose, with minor quantitative discrepancies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- FDG
- PET
- methodology
- neurodegeneration
- neuroimaging
- radiation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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