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Powder Compression ...
Powder Compression Properties of Paracetamol, Paracetamol Hydrochloride, and Paracetamol Cocrystals and Coformers
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- Persson, Ann-Sofie (författare)
- Uppsala universitet,Institutionen för farmaci,Department of Pharmacy, Uppsala University
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- Ahmed, Hamzah (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Alderborn, Göran (författare)
- Uppsala universitet,Institutionen för farmaci,Department of Pharmacy, Uppsala University
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2018
- 2018
- Engelska.
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Ingår i: Journal of Pharmaceutical Sciences. - : ELSEVIER SCIENCE INC. - 0022-3549 .- 1520-6017. ; 107:7, s. 1920-1927
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The objectivewas to study the relationship between crystal structure, particle deformation properties, and tablet-forming ability for the monoclinic formof paracetamol (PRA), 2 cocrystals and a salt crystal of PRA in addition to 2 coformers (oxalic acid and 4,4'-bipyridine). Thus, the structure-property-performance relationship was investigated. Analytical powder compression was used for determination of effective plasticity, as inferred from the Heckel yield pressure and the Frenning parameter, and the elastic deformation was determined from in-die tablet elastic recovery. The plasticity could not be linked to the crystal lattice structure as crystals containing zig-zag layers displayed similar plasticity as crystals containing slip planes. In addition, crystals containing slip planes displayed both high and low plasticity. The mechanical properties could not be linked to the tablet-forming ability as the tablet tensile strength, unexpectedly, displayed a tendency to reduce with increased plasticity. Furthermore, the elastic deformation could not explain the tablet-forming ability. It was concluded that no relationship between structure-property-performance for PRA and its cocrystals and salt could be established. Thus, it was indicated that to establish such a relationship, an improved knowledge of crystallographic structure and interparticle bonding during compaction is needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- mechanical properties
- compression
- compaction
- cocrystals
- crystal structure
- Health Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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