Hydride-transfer transition structure as a possible unifying redox step for describing the branched mechanism of glutathione reductase. Molecular-electronic antecedents

• For glutathione reductase (GR), a mammalian reduced nicotinamide adenine dinucleotide phosphate dependent flavoenzyme participating in free-radical detoxification pathways, we present a quantum chemical study addressing aspects of its electronic mechanism

Nyckelord

branched mechanism; glutathione reductase; catalytic mechanism; transposed hydride transfer; proton relays; CATALYTIC MECHANISM; ENZYME; RESOLUTION; BINDING; MODELS; FLAVINS; SITE; SCF; OLD

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