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Prognostic value of...
Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth
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- Sundermann, Alexandra C. (författare)
- Vanderbilt Univ, Med Ctr, Inst Med & Publ Hlth, Vanderbilt Epidemiol Ctr, Nashville, TN USA
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- Saum, Keith (författare)
- Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH 45267 USA;Univ Cincinnati, Coll Med, Dept Internal Med, Med Scientist Training Program, Cincinnati, OH 45267 USA
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- Conrad, Kelsey A. (författare)
- Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH 45267 USA;Univ Cincinnati, Coll Med, Dept Internal Med, Pathobiol & Mol Med Grad Program, Cincinnati, OH 45267 USA
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- Russell, Hannah M. (författare)
- Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH 45267 USA;Univ Cincinnati, Coll Med, Dept Internal Med, Pathobiol & Mol Med Grad Program, Cincinnati, OH 45267 USA
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- Edwards, Todd L. (författare)
- Vanderbilt Univ, Med Ctr, Inst Med & Publ Hlth, Div Epidemiol,Dept Med,Vanderbilt Genet Inst, Nashville, TN USA
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- Mani, Kevin, 1975- (författare)
- Uppsala universitet,Kärlkirurgi
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- Björck, Martin (författare)
- Uppsala universitet,Kärlkirurgi
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- Wanhainen, Anders (författare)
- Uppsala universitet,Kärlkirurgi
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- Owens, A. Phillip, III (författare)
- Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH 45267 USA;Univ Cincinnati, Coll Med, Dept Internal Med, Pathobiol & Mol Med Grad Program, Cincinnati, OH 45267 USA
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(creator_code:org_t)
- 2018-11-15
- 2018
- Engelska.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 2:22, s. 3088-3096
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Abdominal aortic aneurysm (AAA) is associated with high morbidity and mortality and is an established cause of unbalanced hemostasis. A number of hemostatic biomarkers have been associated with AAA; however, the utility of hemostatic biomarkers in AAA diagnosis and prognosis is unclear. The aim of the present study was to characterize the potential prognostic value of D-dimer and markers of altered hemostasis in a large cohort of patients with AAAs characterized by either fast or slow aneurysm growth (frequency matched for baseline diameter) and subaneurysmal dilations. We measured plasma concentrations of thrombin-antithrombin (TAT) complex, platelet factor 4 (PF4), and D-dimer in 352 patients with either fast-growing AAAs (>2 mm/y), slow-growing AAAs (<2 mm/y), subaneurysmal aortic dilations, or nonaneurysmal aortas. Plasma D-dimer and TAT were significantly elevated in both AAA and subaneurysmal dilation patients compared with controls. Individuals with D-dimer levels >= 500 ng/mL had 3.09 times the odds of subaneurysms, 6.23 times the odds of slow-growing AAAs, and 7.19 times the odds of fast-growing AAAs than individuals with D-dimer level <500 ng/mL. However, no differences in D-dimer concentration were noted between fast- and slow-growing aneurysms. Plasma D-dimer and TAT were strong independent predictors of AAA growth rate with multivariate analysis revealing a 500-ng/mL increase in D-dimer or 1-mu g/mL increase in TAT led to additional 0.21-mm and 0.24-mm changes in aortic diameter per year, respectively. Rising levels of plasma TAT, in addition to D-dimer, may predict disease progression and aneurysm growth in patients with AAA or subaneurysmal dilation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Sundermann, Alex ...
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Saum, Keith
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Conrad, Kelsey A ...
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Russell, Hannah ...
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Edwards, Todd L.
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Mani, Kevin, 197 ...
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Björck, Martin
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Wanhainen, Ander ...
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Owens, A. Philli ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Blood Advances
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Uppsala universitet