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Fusidic Acid :
Fusidic Acid : A Neglected Risk Factor for Statin-Associated Myopathy
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- Rönnqvist, Josefine (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Hallberg, Pär, 1974- (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Uppsala Univ Hosp, Uppsala, Sweden;Uppsala Univ, Dept Med Sci, Clin Pharmacol & Sci Life Lab, Uppsala, Sweden
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- Yue, Qun-Ying (författare)
- Swedish Med Prod Agcy, Uppsala, Sweden
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- Wadelius, Mia (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2018-12-04
- 2018
- Engelska.
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Ingår i: Clinical Medicine Insights. - : SAGE Publications. - 1179-5468. ; 12
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Abstract
Ämnesord
Stäng
- Background: Statins are widely used lipid-lowering drugs used for the prevention of cardiovascular disease. Statins are known to cause myopathy, an adverse drug reaction with various clinical features rhabdomyolysis.Objective: To describe clinical characteristics of statin-treated individuals who experienced myopathy and identify risk factors of statin-associated myopathy.Methods: A retrospective study was conducted on cases of statin-associated myopathy reported to the Swedish Medical Products Agency. Clinical factors were compared between cases and statin-treated controls not diagnosed with myopathy. Statistical methods were univariate and multivariate logistic regression and results were presented as odds ratio (OR) with 95% confidence interval (CI). To correct for multiple comparisons, the cutoff for statistical significance was set to P < .0017.Results: In total, 47 cases of statin-associated myopathy were compared with 3871 treated controls. Rhabdomyolysis was diagnosed in 51% of the cases. Markers for cardiovascular disease were more common in cases than controls. Statistical analysis revealed the following independent risk factors for myopathy: high statin dose (OR = 1.54, calculated using the standard deviation 19.82, 95% CI = 1.32-1.80, P < .0001), and concomitant treatment with fusidic acid (OR = 1002, 95% CI = 54.55-18 410, P < .0001), cyclosporine (OR = 34.10, 95% CI = 4.43-262.45, P = .0007), and gemfibrozil (OR = 12.35, 95% CI = 2.38-64.10, P = .0028).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- adverse drug reactions
- cardiovascular drugs
- drug-induced disorders
- drug safety
- dyslipidemia
- hypercholesterolemia
- hyperlipidemia
- myopathy and statins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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