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Real-world treatmen...
Real-world treatment patterns, resource use and costs of treating uncontrolled carcinoid syndrome and carcinoid heart disease : a retrospective Swedish study
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- Lesén, Eva (författare)
- PharmaLex, Gothenburg, Sweden
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- Björstad, Ase (författare)
- PharmaLex, Gothenburg, Sweden
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- Björholt, Ingela (författare)
- PharmaLex, Gothenburg, Sweden
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- Marlow, Tom (författare)
- PharmaLex, Gothenburg, Sweden
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- Bollano, Entela (författare)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden
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- Feuilly, Marion (författare)
- Ipsen Pharma, Boulogne, France
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- Marteau, Florence (författare)
- Ipsen Pharma, Boulogne, France
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- Welin, Staffan (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Elf, Anna-Karin (författare)
- Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Sweden
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- Johanson, Viktor (författare)
- Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Sweden
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(creator_code:org_t)
- 2018-11-19
- 2018
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 53:12, s. 1509-1518
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: To quantify healthcare resource use (HRU) and costs in relation to carcinoid syndrome (CS) and carcinoid heart disease (CHD) in a real-world setting, and to provide perspective on treatment patterns.Materials and methods: Patient data and HRU were collected retrospectively from three Swedish healthcare registers. Adult patients diagnosed with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) grade 1 or 2 and CS who purchased somatostatin analogs (SSAs), and experienced controlled (defined by SSAs use) and uncontrolled (defined by SSAs dose escalation) CS for ≥8 months during the study period were included. Patients diagnosed with CHD from the date of the GEP-NET diagnosis were included in the CHD study group.Results: Overall, total HRU cost increased with uncontrolled CS and CHD. Total resource cost was 15,500€/patient during controlled CS (8 months), rising to 21,700€/patient during uncontrolled CS (8 months), representing an increase of ∼40% (6200€/patient). Costs/patient were driven mainly by SSA use, tumor-related medical interventions and examinations. The total mean cost/year of disease was 1100€/patient without CHD, compared to 4600€/patient with CHD, a difference of 3500€/patient. Excluding SSA cost burden, the main drivers of increased cost in CHD patients were surgical interventions and echocardiography.Conclusions: This study provides a comprehensive overview of the treatment patterns and burden of uncontrolled CS symptoms and CHD using Swedish national register data. Increases in medical interventions and examinations HRU and increased SSA use suggest that SSA dose escalation alone may not effectively control the symptoms associated with uncontrolled CS, highlighting an unmet treatment need in this patient group.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Neuroendocrine tumors
- healthcare resource use
- carcinoid syndrome
- carcinoid heart disease
- treatment patterns
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lesén, Eva
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Björstad, Ase
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Björholt, Ingela
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Marlow, Tom
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Bollano, Entela
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Feuilly, Marion
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visa fler...
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Marteau, Florenc ...
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Welin, Staffan
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Elf, Anna-Karin
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Johanson, Viktor
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Scandinavian Jou ...
- Av lärosätet
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Uppsala universitet