Trismus in patients with head and neck cancer and 5-year overall survival

• Background: Trismus is a common complication of radiotherapy for head and neck cancer but its impact on survival is unknown.Aims/Objectives: This prospective study evaluates the incidence of trismus in patients with head and neck cancer receiving radiotherapy and the impact of trismus on 5-year overall survival.Material and methods: Two hundred forty-four patients with head and neck cancer were included. All patients received instructions on jaw exercises and were evaluated before initiation of radiotherapy and at 2, 6, and 12 months after termination of radiotherapy.Results: One year after treatment 25% had a reduced maximum interincisal opening (MIO) of 13 mm or more as compared to the pretreatment MIO. Trismus was most prevalent in patients with oral and oropharyngeal cancer. A trend towards worse 5-year overall survival was seen among patients with trismus.Conclusions: The trismus rate was approximately 30% at 12 months. Jaw exercises should primarily be offered to patients with oral and oropharyngeal cancer who are most likely to benefit. Further studies are required to investigate the effect of trismus on survival.Significance: This study identifies patients likely to benefit from jaw exercises and provides basis for further research on trismus and survival.

• 背景：牙关紧闭症是头颈癌放射治疗的常见并发症, 但它对生存的影响尚不清楚。目的：这项前瞻性研究评估接受放射治疗的头颈癌患者牙关紧闭症的发生率以及其对5年总生存率的影响。材料和方法：共224名头颈癌患者纳入研究。所有患者均接受了下颌运动的训练, 并在放疗开始前和放疗结束后的2、6和12个月接受了评估。结果：与治疗前最大切牙间开口（MIO）相比, 治疗一年后, 25％的MIO降低了13 mm或更多。牙关紧闭症在口腔和口咽癌患者中最常见。在牙关紧闭症患者中观察到5年总体生存率下降的趋势。结论：在12个月时, 牙关紧闭症发生率约为30％。下颌运动应该主要提供给最有可能受益的口腔和口咽癌患者。需要进一步的研究来研究牙关紧闭症对生存的影响。意义：本研究确定患者可能从下颌运动中获益, 并为进一步研究牙关紧闭症和生存提供了基础。

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)

Nyckelord

Trismus

head and neck cancer

radiotherapy

long-term follow-up

overall survival

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