Structural basis for 4-hydroxyalkenal activity in human glutathione transferase A4-4

• The Alpha class glutathione transferase A4-4 (GST A4-4) detoxifies products of lipid peroxidation, e.g.4-hydroxynonenal, by a Michael-addition to glutathione. Another Alpha class enzyme, GST A1-1, is not as efficient although the structures of the enzymes

Nyckelord

4-hydroxynonenal; glutathione transferase; protein redesign

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