Sökning: id:"swepub:oai:DiVA.org:uu-390073" >
Toxicological effec...
Toxicological effects of furan on the reproductive system of male rats : An "in vitro" and "in vivo"-based endocrinological and spermatogonial study
-
- Rehman, Humaira (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad, Pakistan
-
- Jahan, Sanwat (författare)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad, Pakistan
-
- Ullah, Imdad (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Abbottabad Univ Sci & Technol, Dept Zool, Havalian, Abbottabad, Pakistan
-
visa fler...
-
- Winberg, Svante (författare)
- Abbottabad Univ Sci & Technol, Dept Zool, Havalian, Abbottabad, Pakistan
-
visa färre...
-
(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2019
- 2019
- Engelska.
-
Ingår i: Chemosphere. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0045-6535 .- 1879-1298. ; 230, s. 327-336
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Furan is a colorless toxic chemical produced in various food items during heat processing and in chemical industries. Both in vitro and in vivo studies have reported that it induces oxidative stress and endocrine disruption; however, limited data are available regarding the effects of furan on the reproduction of mammals. In the present study, an in vitro experiment was designed to investigate the direct effects of furan exposure on oxidative stress and testosterone concentration in rat testicular tissue. Furan not only generated high oxidative stress but also decreased antioxidant enzyme activity in the testicular tissue. On the basis of in vitro study results, an in vivo sub-chronic exposure study was performed. Male rats were orally exposed to different concentrations of furan (0, 5, 10, 20, and 40 mg kg(-1)). An increase (P < 0.05) of reactive oxygen species (ROS) and of the lipid profile (cholesterol, triglycerides, and LDL) in higher dose treatment groups of furan was observed, while total protein content and antioxidant enzyme activity were considerably decreased after furan exposure. Also, plasma and intratesticular testosterone concentrations were reduced in high-dose treatment groups. Sperm parameters such as sperm viability, sperm count, and sperm motility showed a decrease (P < 0.05) in a dose-dependent manner. Histopathological findings revealed significant alterations in testis and epididymis tissues. These results confirm that furan can induce toxic effects on the reproductive system of male rats.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Furan
- Histopathology
- Testosterone
- Antioxidant enzyme
- Sperm parameters
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas