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Genome-Wide Analysi...
Genome-Wide Analysis of Long Non-Coding RNA Profiles in Canine Oral Melanomas
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- Hitte, Christophe (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Le Beguec, Celine (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Cadieu, Edouard (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Wucher, Valentin (författare)
- Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Dr Aiguader 88, Barcelona 08003, Spain
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- Primot, Aline (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Prouteau, Pings (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Botherel, Nadine (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Hedan, Benoit (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Lindblad-Toh, Kerstin (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
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- Andre, Catherine (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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- Derrien, Thomas (författare)
- Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France
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(creator_code:org_t)
- 2019-06-23
- 2019
- Engelska.
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Ingår i: Genes. - : MDPI. - 2073-4425 .- 2073-4425. ; 10:6
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Mucosal melanomas (MM) are rare aggressive cancers in humans, and one of the most common forms of oral cancers in dogs. Similar biological and histological features are shared between MM in both species, making dogs a powerful model for comparative oncology studies of melanomas. Although exome sequencing recently identified recurrent coding mutations in canine MM, little is known about changes in non-coding gene expression, and more particularly, in canine long non-coding RNAs (lncRNAs), which are commonly dysregulated in human cancers. Here, we sampled a large cohort (n = 52) of canine normal/tumor oral MM from three predisposed breeds (poodles, Labrador retrievers, and golden retrievers), and used deep transcriptome sequencing to identify more than 400 differentially expressed (DE) lncRNAs. We further prioritized candidate lncRNAs by comparative genomic analysis to pinpoint 26 dog-human conserved DE lncRNAs, including SOX21-AS, ZEB2-AS, and CASC15 lncRNAs. Using unsupervised co-expression network analysis with coding genes, we inferred the potential functions of the DE lncRNAs, suggesting associations with cancer-related genes, cell cycle, and carbohydrate metabolism Gene Ontology (GO) terms. Finally, we exploited our multi-breed design to identify DE lncRNAs within breeds. This study provides a unique transcriptomic resource for studying oral melanoma in dogs, and highlights lncRNAs that may potentially be diagnostic or therapeutic targets for human and veterinary medicine.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- mucosal melanoma
- dogs
- transcriptome sequencing
- long non-coding RNAs (lncRNAs)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hitte, Christoph ...
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Le Beguec, Celin ...
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Cadieu, Edouard
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Wucher, Valentin
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Primot, Aline
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Prouteau, Pings
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visa fler...
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Botherel, Nadine
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Hedan, Benoit
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Lindblad-Toh, Ke ...
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Andre, Catherine
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Derrien, Thomas
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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Genes
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Uppsala universitet