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Longitudinal transc...
Longitudinal transcriptomic and genetic landscape of radiotherapy response in canine melanoma
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- Giannuzzi, Diana (författare)
- Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Padua, Italy
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- Marconato, Laura (författare)
- Ctr Oncol Vet, Bologna, Italy
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- Elgendy, Ramy (författare)
- Uppsala universitet,Neuroonkologi
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- Ferraresso, Serena (författare)
- Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Padua, Italy
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- Scarselli, Elisa (författare)
- Nouscom Srl, Rome, Italy
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- Fariselli, Piero (författare)
- Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Padua, Italy
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- Nicosia, Alfredo (författare)
- Nouscom AG, Basel, Switzerland;Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy;CEINGE Biotecnol Avanzate Scarl, Naples, Italy
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- Pegolo, Sara (författare)
- Univ Padua, Dept Agron Food Nat Resources Anim & Environm, Padua, Italy
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- Leoni, Guido (författare)
- Nouscom Srl, Rome, Italy
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- Laganga, Paola (författare)
- Ctr Oncol Vet, Bologna, Italy
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- Leone, Vito F. (författare)
- Ctr Oncol Vet, Bologna, Italy
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- Giantin, Mery (författare)
- Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Padua, Italy
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- Troise, Fulvia (författare)
- Nouscom Srl, Rome, Italy
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- Dacasto, Mauro (författare)
- Univ Padua, Dept Comparat Biomed & Food Sci, Viale Univ 16, I-35020 Padua, Italy
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- Aresu, Luca (författare)
- Univ Turin, Dept Vet Sci, Turin, Italy
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(creator_code:org_t)
- 2019-03-27
- 2019
- Engelska.
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Ingår i: Veterinary and Comparative Oncology. - : WILEY. - 1476-5810 .- 1476-5829. ; 17:3, s. 308-316
- Relaterad länk:
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https://cris.unibo.i...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Canine malignant melanoma (MM) is a highly aggressive tumour with a low survival rate and represents an ideal spontaneous model for the human counterpart. Considerable progress has been recently obtained, but the therapeutic success for canine melanoma is still challenging. Little is known about the mechanisms beyond pathogenesis and melanoma development, and the molecular response to radiotherapy has never been explored before. A faster and deeper understanding of cancer mutational processes and developing mechanisms are now possible through next generation sequencing technologies. In this study, we matched whole exome and transcriptome sequencing in four dogs affected by MM at diagnosis and at disease progression to identify possible genetic mechanisms associated with therapy failure. According to previous studies, a genetic similarity between canine MM and its human counterpart was observed. Several somatic mutations were functionally related to MAPK, PI3K/AKT and p53 signalling pathways, but located in genes other than BRAF, RAS and KIT. At disease progression, several mutations were related to therapy effects. Natural killer cell-mediated cytotoxicity and several immune-system-related pathways resulted activated opening a new scenario on the microenvironment in this tumour. In conclusion, this study suggests a potential role of the immune system associated to radiotherapy in canine melanoma, but a larger sample size associated with functional studies are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- dog
- exome sequencing
- melanoma
- radiation therapy
- RNA-seq
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Giannuzzi, Diana
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Marconato, Laura
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Elgendy, Ramy
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Ferraresso, Sere ...
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Scarselli, Elisa
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Fariselli, Piero
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visa fler...
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Nicosia, Alfredo
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Pegolo, Sara
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Leoni, Guido
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Laganga, Paola
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Leone, Vito F.
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Giantin, Mery
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Troise, Fulvia
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Dacasto, Mauro
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Aresu, Luca
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Veterinary and C ...
- Av lärosätet
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Uppsala universitet