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Pharmacological interventions for chronic pain in children : an overview of systematic reviews

Eccleston, Christopher (författare)
Univ Bath, Ctr Pain Res, Bath BA2 7AY, Avon, England;Univ Ghent, Dept Clin & Hlth Psychol, Ghent, Belgium
Fisher, Emma (författare)
Univ Bath, Ctr Pain Res, Bath BA2 7AY, Avon, England;Oxford Univ Hosp, Pain Palliat & Support Care, Oxford, England
Cooper, Tess E. (författare)
Univ Sydney, Fac Med & Hlth, Sch Publ Hlth, Sydney, NSW, Australia
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Gregoire, Marie-Claude (författare)
Dalhousie Univ, Dept Pediat, Halifax, NS, Canada
Heathcote, Lauren C. (författare)
Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA
Krane, Elliot (författare)
Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Perintnv, Palo Alto, CA 94304 USA
Lord, Susan M. (författare)
Hunter Med Res Inst, Childrens Complex Pain Serv, John Hunter Childrens Hosp, Newcastle, NSW, Australia;Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia
Sethna, Navil F. (författare)
Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA
Anderson, Anna-Karenia (författare)
Royal Marsden Hosp, London, England
Anderson, Brian (författare)
Univ Auckland, Dept Anaesthesiol, Auckland, New Zealand
Clinch, Jacqueline (författare)
Univ Bristol, Bristol Royal Childrens Hosp, Bristol, Avon, England;Royal Natl Hosp Rheumat Dis, Bath, Avon, England
Gray, Andrew L. (författare)
Univ KwaZulu Natal, Div Pharmacol, Discipline Pharmaceut Sci, Durban, South Africa
Gold, Jeffrey, I (författare)
Univ Southern Calif, Keck Sch Med, Anesthesiol Pediat & Psychiat & Behav Sci, Los Angeles, CA USA;Childrens Hosp Los Angeles, Pediat Pain Management Clin, Los Angeles, CA 90027 USA
Howard, Richard F. (författare)
Great Ormond St Hosp Sick Children, Dept Anaesthesia & Pain Med, London, England
Ljungman, Gustaf, 1958- (författare)
Uppsala universitet,Barnneurologi/Barnonkologi
Moore, R. Andrew (författare)
Univ Oxford, Churchill, Dept Clin Neurosci, Pain Res,Nuffield, Oxford, England
Schechter, Neil (författare)
Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
Wiffen, Philip J. (författare)
Univ Oxford, Churchill, Dept Clin Neurosci, Pain Res,Nuffield, Oxford, England
Wilkinson, Nick M. R. (författare)
Kings Coll London, Evelina London Childrens Hosp, Dept Paediat, London, England
William, David G. (författare)
Great Ormond St Hosp Children NHS Fdn Trust, Anaesthet Dept, London, England
Wood, Chantal (författare)
Univ Limoges, Univ Hosp Limoges, Chron Pain Ctr, Dept Rheumatol, Haute Vienne, France
van Tilburg, Miranda A. L. (författare)
Campbell Univ, Coll Pharm & Hlth Sci, Buies Creek, NC 27506 USA;Univ N Carolina, Div Gastroenterol & Hepatol, Chapel Hill, NC 27515 USA
Zernikow, Boris (författare)
Childrens & Adolescents Hosp, German Paediat Pain Ctr, Datteln, Germany;Witten Herdecke Univ, Childrens Pain Therapy & Paediat Palliat Care, Fac Hlth, Sch Med, Witten, Germany
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 (creator_code:org_t)
Ovid Technologies (Wolters Kluwer Health), 2019
2019
Engelska.
Ingår i: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 160:8, s. 1698-1707
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic cancer-related pain (CCRP). We searched the Cochrane Database of Systematic Reviews, Medline, EMBASE, and DARE for systematic reviews from inception to March 2018. We conducted reference and citation searches of included reviews. We included children (0-18 years of age) with CNCP or CCRP. We extracted the review characteristics and primary outcomes of >= 30% participant-reported pain relief and patient global impression of change. We sifted 704 abstracts and included 23 systematic reviews investigating children with CNCP or CCRP. Seven of those 23 reviews included 6 trials that involved children with CNCP. There were no randomised controlled trials in reviews relating to reducing pain in CCRP. We were unable to combine data in a meta-analysis. Overall, the quality of evidence was very low, and we have very little confidence in the effect estimates. The state of evidence of randomized controlled trials in this field is poor; we have no evidence from randomised controlled trials for pharmacological interventions in children with cancer-related pain, yet cannot deny individual children access to potential pain relief.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Adolescents
Cancer-related pain
Children
Chronic pain
Pharmacological interventions
Systematic review

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