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A Vitamin D, Calciu...
A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults : The PROVIDE Study
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- Hill, Tom R. (författare)
- Newcastle Univ, Human Nutr Res Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
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- Verlaan, Sjors (författare)
- Nutricia Adv Med Nutr, Danone Nutricia Res, Utrecht, Netherlands; Amsterdam UMC, Dept Internal Med, Sect Gerontol & Geriatr, Amsterdam, Netherlands
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- Biesheuvel, Egbert (författare)
- Nutricia Adv Med Nutr, Danone Nutricia Res, Utrecht, Netherlands
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- Eastell, Richard (författare)
- Univ Sheffield, Northern Gen Hosp, Metab Bone Ctr, Acad Unit Bone Metab, Sheffield, S Yorkshire, England
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- Bauer, Juergen M. (författare)
- Carl von Ossietzky Univ Oldenburg, Dept Geriatr Med, Oldenburg, Germany
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- Bautmans, Ivan (författare)
- Vrije Univ Brussel VUB, Frailty Ageing Res Grp FRIA, Brussels, Belgium
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- Brandt, Kirsten (författare)
- Newcastle Univ, Human Nutr Res Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
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- Donini, Lorenzo M. (författare)
- Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Human Nutr, Rome, Italy
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- Maggio, Marcello (författare)
- Univ Parma, Sect Geriatr, Dept Clin & Expt Med, Parma, Italy
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- Mets, Tony (författare)
- Vrije Univ Brussel VUB, Frailty Ageing Res Grp FRIA, Brussels, Belgium
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- Seal, Chris J. (författare)
- Newcastle Univ, Human Nutr Res Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
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- Wijers, Sander L. J. (författare)
- Nutricia Adv Med Nutr, Danone Nutricia Res, Utrecht, Netherlands
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- Sieber, Cornel (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Ageing, Erlangen, Germany
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- Cederholm, Tommy (författare)
- Karolinska Institutet,Uppsala universitet,Geriatrik
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- Aspray, Terry J. (författare)
- Newcastle Univ, Freeman Hosp, Bone Clin, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
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(creator_code:org_t)
- 2019-07-23
- 2019
- Engelska.
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Ingår i: Calcified Tissue International. - : Springer Science and Business Media LLC. - 0171-967X .- 1432-0827. ; 105:4, s. 383-391
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://iris.uniroma...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Alterations in musculoskeletal health with advanced age contribute to sarcopenia and decline in bone mineral density (BMD) and bone strength. This decline may be modifiable via dietary supplementation. To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of bone health. Participants (n 380) were participants of the PROVIDE study, a 13-week, multicenter, randomized, controlled, double-blind, 2 parallel-group study among non-malnourished older participants (≥ 65 years) with sarcopenia [determined by Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index (SMI; skeletal muscle mass/BW × 100) ≤ 37% in men and ≤ 28% in women using bioelectric impedance analysis] Supplementation of a vitamin D, calcium and leucine-enriched whey protein drink that comprises a full range of micronutrients (active; 2/day) was compared with an iso-caloric control. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), biochemical markers of bone formation (osteocalcin; OC, procollagen type 1 amino-terminal propeptide; P1NP) and resorption (carboxy-terminal collagen crosslinks; CTX), insulin like growth factor 1 (IGF-1) and total-body BMD were analysed pre- and post-intervention. Serum 25(OH)D concentrations increased from 51.1 ± 22.9 nmol/L (mean ± SD) to 78.9 ± 21.1 nmol/L in the active group (p < 0.001 vs. control). Serum PTH showed a significant treatment difference (p < 0.001) with a decline in the active group, and increase in the control group. Serum IGF-1 increased in the active group (p < 0.001 vs. control). Serum CTX showed a greater decline in the active group (p = 0.001 vs. control). There were no significant differences in serum OC or P1NP between groups during the intervention. Total body BMD showed a small (0.02 g/cm2; ~ 2%) but significant increase in the active group after supplementation (p = 0.033 vs. control). Consuming a vitamin D, calcium and leucine-enriched whey protein supplement for 13 weeks improved 25(OH)D, suppressed PTH and had small but positive effects on BMD, indicative of improved bone health, in sarcopenic non-malnourished older adults.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Vitamin D
- Leucine
- Intervention
- Bone turnover
- BMD
- PROVIDE Study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hill, Tom R.
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Verlaan, Sjors
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Biesheuvel, Egbe ...
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Eastell, Richard
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Bauer, Juergen M ...
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Bautmans, Ivan
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visa fler...
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Brandt, Kirsten
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Donini, Lorenzo ...
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Maggio, Marcello
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Mets, Tony
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Seal, Chris J.
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Wijers, Sander L ...
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Sieber, Cornel
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Cederholm, Tommy
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Aspray, Terry J.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Uppsala universitet
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Karolinska Institutet