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Circulating Tissue Factor-Positive Procoagulant Microparticles in Patients with Type 1 Diabetes

Zhang, Chenghui (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Peoples Govt Tibetan Autonomous Reg, Hosp Chengdu Off, Dept Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China
Ou, Qing (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Gu, Yan (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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Cheng, Gaiping (författare)
Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R China
Du, Rong (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Peoples Govt Tibetan Autonomous Reg, Hosp Chengdu Off, Dept Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China
Yuan, Li (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Cordiner, Ruth L. M. (författare)
Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
Kang, Deying (författare)
Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu 610041, Sichuan, Peoples R China
Zhang, Jiaying (författare)
Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610041, Sichuan, Peoples R China
Huang, Qiaorong (författare)
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Yu, Chuan (författare)
Sichuan Univ, West China Sch Publ Hlth, Dept Hlth Related Social & Behav Sci, Chengdu 610041, Sichuan, Peoples R China
Kang, Li (författare)
Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland;Univ Dundee, Ninewells Hosp, Div Syst Med, Dundee DD1 9SY, Scotland
Wang, Xuan, 1984- (författare)
Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab,Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
Sun, Xin (författare)
Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu 610041, Sichuan, Peoples R China
Mo, Xianming (författare)
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Tian, Haoming (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Pearson, Ewan R. (författare)
Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
Meng, Wentong (författare)
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
Li, Sheyu (författare)
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
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 (creator_code:org_t)
DOVE MEDICAL PRESS LTD, 2019
2019
Engelska.
Ingår i: Diabetes, Metabolic Syndrome and Obesity. - : DOVE MEDICAL PRESS LTD. - 1178-7007. ; 12, s. 2819-2828
Relaterad länk:
https://doi.org/10.2...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aim: To investigate the count of circulating tissue factor-positive (TF+) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM).Methods: This case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive (PS+) MPs and TF(+)PS(+)MPs and the subgroups derived from different cell types were measured in the peripheral blood sample of the two groups using multicolor flow cytometric assay. We compared the counts of each MP between groups as well as the ratio of the TF(+)PS(+)MPs and PS(+)MPs (TF(+)PS(+)MPs/PS(+)MPs).Results: We recruited 36 patients with T1DM and 36 matched healthy controls. Compared with healthy volunteers, PS(+)MPs, TF(+)PS(+)MPs and TF(+)PS(+)MPs/PS(+)MPs were elevated in patients with T1DM (PS(+)MPs: 1078.5 +/- 158.08 vs 686.84 +/- 122.04/mu L, P <0.001; TF(+)PS(+)MPs: 202.10 +/- 47.47 vs 108.33 +/- 29.42/mu L, P <0.001; and TF(+)PS(+)MPs/PS(+)MPs: 0.16 +/- 0.04 vs 0.19 +/- 0.05, P = 0.004), mostly derived from platelet, lymphocytes and endothelial cells. In the subgroup analysis, the counts of total and platelet TF(+)PS(+)MPs were increased in patients with diabetic retinopathy (DR) and with higher HbA1c, respectively.Conclusion: Circulating TF(+)PS(+)MPs and those derived from platelet, lymphocytes and endothelial cells were elevated in patients with T1DM.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

type 1 diabetes mellitus
microparticles
tissue factor
diabetic retinopathy

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