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Medulloblastomics r...
Medulloblastomics revisited : biological and clinical insights from thousands of patients
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- Hovestadt, Volker (författare)
- Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA;Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA;Broad Inst Harvard & MIT, Cambridge, MA USA
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- Ayrault, Olivier (författare)
- PSL Res Univ, CNRS, Inst Curie, INSERM,UMR, Orsay, France;Univ Paris Saclay, Univ Paris Sud, INSERM, U1021,CNRS,UMR 3347, Orsay, France
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- Johansson Swartling, Fredrik K., 1975- (författare)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Robinson, Giles W. (författare)
- St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA
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- Pfister, Stefan M. (författare)
- Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany;German Canc Res Ctr, Div Paediat Neurooncol, Heidelberg, Germany;German Canc Consortium DKTK, Heidelberg, Germany;Heidelberg Univ Hosp, Dept Paediat Haematol & Oncol, Heidelberg, Germany
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- Northcott, Paul A. (författare)
- St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA
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(creator_code:org_t)
- 2019-12-09
- 2020
- Engelska.
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Ingår i: Nature Reviews. Cancer. - : NATURE PUBLISHING GROUP. - 1474-175X .- 1474-1768. ; 20:1, s. 42-56
- Relaterad länk:
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https://hal.archives...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has recently been the focus of intensive molecular profiling efforts, profoundly advancing our understanding of biologically and clinically heterogeneous disease subgroups. Genomic, epigenomic, transcriptomic and proteomic landscapes have now been mapped for an unprecedented number of bulk samples from patients with medulloblastoma and, more recently, for single medulloblastoma cells. These efforts have provided pivotal new insights into the diverse molecular mechanisms presumed to drive tumour initiation, maintenance and recurrence across individual subgroups and subtypes. Translational opportunities stemming from this knowledge are continuing to evolve, providing a framework for improved diagnostic and therapeutic interventions. In this Review, we summarize recent advances derived from this continued molecular characterization of medulloblastoma and contextualize this progress towards the deployment of more effective, molecularly informed treatments for affected patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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