Sökning: id:"swepub:oai:DiVA.org:uu-406057" >
Anti-ageing and ant...
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice
-
- Liu, Xiao-yan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China;China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
-
- Liu, Dan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
-
- Lin, Guo-peng (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
-
visa fler...
-
- Wu, Yi-jing (författare)
- Minjiang Univ, Inst Oceanog, Fuzhou 350108, Peoples R China
-
- Gao, Lu-ying (författare)
- Nanjing Med Univ, Nanjing Hosp 1, Dept Pediat, Nanjing 210006, Peoples R China
-
- Ai, Chao (författare)
- South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
-
- Huang, Yi-fan (författare)
- Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou 350002, Peoples R China
-
- Wang, Ming-fu (författare)
- Providence Univ, Food & Nutr Dept, Taichung 43301, Taiwan
-
- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi
-
- Chen, Xin-hua (författare)
- Fujian Agr & Forestry Univ, Inst Oceanol, Key Lab Marine Biotechnol Fujian Prov, Fuzhou 350002, Peoples R China
-
- Zhao, Chao (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China;Univ Macau, State Key Lab Qual Control Chinese Med, Inst Chinese Med Sci, Taipa, Macau, Peoples R China
-
visa färre...
-
(creator_code:org_t)
- ELSEVIER, 2019
- 2019
- Engelska.
-
Ingår i: International Journal of Biological Macromolecules. - : ELSEVIER. - 0141-8130 .- 1879-0003. ; 139, s. 342-351
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Oligosaccharides from green algae Ulva lactuca (ULO) and Enteromorpha prolifera (EPO) were used for investigation of anti-ageing effects and the underlying mechanism in SAMP8 mice. The structural properties of ULO and EPO were analyzed by fourier-transform infrared spectroscopy, gas chromatography-mass spectrometry, and agarose gel electrophoresis. These oligosaccharides enhanced the glutathione, superoxide dismutase, catalase, and telomerase levels and total antioxidant capicity, and decreased the levels of malondialdehyde and advanced glycation end products. After ULO and EPO treatment, the levels of inflammatory factors, including IFN-gamma, TNF-alpha, and IL-6, decreased; the BDNF and ChAT levels increased; and hippocampal neurons were protected. Downregulation of the p53 and FOXO1 genes and upregulation of the Sirt1 gene indicated that ULO and EPO have potential therapeutic effects in the prevention of ageing in SAMP8 mice. By 16S rRNA gene high-throughput sequencing, the abundance of Desulfovibrio was discovered to be markedly different in mice treated with ULO and EPO. The abundances of Verrucomicrobiaceae, Odoribacteraceae, Mogibacteriaceae, Planococcaceae, and Coriobacteriaceae were positively correlated with age-related indicators. These results demonstrated that oligosaccharides from U. lactuca and E. prolifera are ideal candidate compounds that can be used in functional foods and pharmaceuticals to prevent ageing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Ulva lactuca
- Enteromorpha prolifera
- Oligosaccharides
- Anti-ageing
- Gut microbiota
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Liu, Xiao-yan
-
Liu, Dan
-
Lin, Guo-peng
-
Wu, Yi-jing
-
Gao, Lu-ying
-
Ai, Chao
-
visa fler...
-
Huang, Yi-fan
-
Wang, Ming-fu
-
El-Seedi, Hesham
-
Chen, Xin-hua
-
Zhao, Chao
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Uppsala universitet