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Clinical Significan...
Clinical Significance of Alloantibodies in Hand Transplantation : A Multicenter Study
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- Berglund, Erik (författare)
- Karolinska Institutet
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- Andersen Ljungdahl, Mette (författare)
- Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden
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- Bogdanovic, Darko (författare)
- Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden
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- Berglund, David, 1984- (författare)
- Uppsala universitet,Klinisk immunologi
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- Wadstroem, Jonas (författare)
- Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden
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- Kowalski, Jan (författare)
- JK Biostat AB, Stockholm, Sweden
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- Brandacher, Gerald (författare)
- Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA
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- Kaminska, Dorota (författare)
- Wroclaw Med Univ, Dept Nephrol & Transplantat Med, Wroclaw, Poland
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- Kaufman, Christina L. (författare)
- Christine M Kleinert Inst Hand & Microsurg, Louisville, KY USA
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- Talbot, Simon G. (författare)
- Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA
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- Azari, Kodi (författare)
- Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Div Plast Surg, Los Angeles, CA 90095 USA
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- Landin, Luis (författare)
- Hosp Univ La Paz, Div Plast & Reconstruct Surg, IdiPaz, FIBHULP, Madrid, Spain
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- Hoehnke, Christoph (författare)
- Klinikum Memmingen, Div Plast & Reconstruct Surg, Memmingen, Germany;Tech Univ Munich, Munich, Germany
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- Dwyer, Karen M. (författare)
- Deakin Univ, Sch Med, Fac Hlth, Geelong, Vic, Australia
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- Cavadas, Pedro C. (författare)
- Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain
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- Thione, Alessandro (författare)
- Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain
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- Clarke, Brendan (författare)
- Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England
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- Kay, Simon (författare)
- Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England
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- Wilks, Dan (författare)
- Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England
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- Iyer, Subramania (författare)
- Amrita Inst Med Sci, Plast Reconstruct Surg, Kochi, Kerala, India
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- Iglesias, Martin (författare)
- Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico
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- Ozkan, Omer (författare)
- Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey
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- Ozkan, Ozlenen (författare)
- Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey
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- Krapf, Johanna (författare)
- Innsbruck Med Univ, Dept Plast & Reconstruct Surg, Innsbruck, Austria
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- Weissenbacher, Annemarie (författare)
- Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria;Univ Oxford, Churchill Hosp, Oxford Transplant Ctr, Nuffield Dept Surg Sci, Oxford, England
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- Petruzzo, Palmina (författare)
- Hop Edouard Herriot, HCL, Dept Transplantat, Lyon, France
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- Schneeberger, Stefan (författare)
- Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2019
- 2019
- Engelska.
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Ingår i: Transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0041-1337 .- 1534-6080. ; 103:10, s. 2173-2182
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background. Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. Methods. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Results. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. Conclusions. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, close monitoring, and the relevance of an HLA class II match in UET recipients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Berglund, Erik
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Andersen Ljungda ...
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Bogdanovic, Dark ...
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Berglund, David, ...
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Wadstroem, Jonas
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Kowalski, Jan
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Brandacher, Gera ...
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Kaminska, Dorota
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Kaufman, Christi ...
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Talbot, Simon G.
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Azari, Kodi
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Landin, Luis
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Hoehnke, Christo ...
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Dwyer, Karen M.
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Cavadas, Pedro C ...
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Thione, Alessand ...
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Clarke, Brendan
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Kay, Simon
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Wilks, Dan
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Iyer, Subramania
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Iglesias, Martin
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Ozkan, Omer
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Ozkan, Ozlenen
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Krapf, Johanna
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Weissenbacher, A ...
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Petruzzo, Palmin ...
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Schneeberger, St ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Transplantation
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet