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Sökning: id:"swepub:oai:DiVA.org:uu-407646" > Mast cell chymase p...

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Madjene, Lydia Celia (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Danelli, Luca (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France;Francis Crick Inst, Retroviral Immunol, London, England
Dahdah, Albert (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
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Vibhushan, Shamila (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Bex-Coudrat, Julie (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Pacreau, Emeline (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Vaugier, Celine (författare)
INSERM, UMR 1163, Lab Cellular & Mol Mech Hematol Disorders & Thera, Paris, France;Paris Descartes Sorbonne Paris Cite Univ, Imagine Inst, Lab Excellence GR Ex, Paris, France;CNRS, ERL 8254, Lab Cellular & Mol Mech Hematol Disorders & Thera, Paris, France
Claver, Julien (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Rolas, Loic (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Pons, Maguelonne (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France;CHU Estaing, Serv Chirurg Pediat, Clermont Ferrand, France
Madera-Salcedo, Iris Karina (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France;Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico
Beghdadi, Walid (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
El Ghoneimi, Alaa (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France;Univ Paris Diderot, Hop Robert Debre, AP HP, Sorbonne Paris Cite,Dept Pediat Surg & Urol, Paris, France
Benhamou, Marc (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Launay, Pierre (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Åbrink, Magnus (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, Immunol Sect, VHC, Uppsala, Sweden
Pejler, Gunnar (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Uppsala University
Moura, Ivan Cruz (författare)
INSERM, UMR 1163, Lab Cellular & Mol Mech Hematol Disorders & Thera, Paris, France;Paris Descartes Sorbonne Paris Cite Univ, Imagine Inst, Lab Excellence GR Ex, Paris, France;CNRS, ERL 8254, Lab Cellular & Mol Mech Hematol Disorders & Thera, Paris, France
Charles, Nicolas (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Daugas, Eric (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France;Hop Univ Bichat Claude Bernard, AP HP, Serv Nephrol, Paris, France
Perianin, Axel (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
Blank, Ulrich (författare)
INSERM, UMRS 1149, Ctr Res Inflammat, Paris, France;CNRS, ERL 8252, Ctr Res Inflammat, Paris, France;Univ Paris Diderot, Ctr Res Inflammat, Lab Excellence INFLAMEX, Sorbonne Paris Cite, Paris, France
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 (creator_code:org_t)
 
ELSEVIER SCIENCE INC, 2020
2020
Engelska.
Ingår i: Kidney International. - : ELSEVIER SCIENCE INC. - 0085-2538 .- 1523-1755. ; 97:3, s. 516-527
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
https://res.slu.se/i...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Here we investigated the role of murine mast cell protease 4 (MCPT4), the functional counterpart of human mast cell chymase, in an experimental model of renal ischemia reperfusion injury, a major cause of acute kidney injury. MCPT4-deficient mice had worsened kidney function compared to wildtype mice. MCPT4 absence exacerbated pathologic neutrophil infiltration in the kidney and increased kidney myeloperoxidase expression, cell death and necrosis. In kidneys with ischemia reperfusion injury, when compared to wildtype mice, MCPT4-deficient mice showed increased surface expression of adhesion molecules necessary for leukocyte extravasation including neutrophil CD162 and endothelial cell CD54. In vitro, human chymase mediated the cleavage of neutrophil expressed CD162 and also CD54, P- and E-Selectin expressed on human glomerular endothelial cells. MCPT4 also dampened systemic neutrophil activation after renal ischemia reperfusion injury as neutrophils expressed more CD11b integrin and produced more reactive oxygen species in MCPT4-deficient mice. Accordingly, after renal injury, neutrophil migration to an inflammatory site distal from the kidney was increased in MCPT4-deficient versus wildtype mice. Thus, contrary to the described overall aggravating role of mast cells, one granule-released mediator, the MCPT4 chymase, exhibits a potent anti-inflammatory function in renal ischemia reperfusion injury by controlling neutrophil extravasation and activation thereby limiting associated damage.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

acute kidney injury
acute rejection
inflammation
ischemia reperfusion

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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