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Physicochemical cha...
Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity
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- Liu, Xiaoyan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
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- Liu, Dan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
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- Chen, Yihan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
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- Zhong, Ruting (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
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- Gao, Luying (författare)
- Nanjing Med Univ, Nanjing Hosp 1, Dept Pediat, Nanjing 210006, Peoples R China
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- Yang, Chengfeng (författare)
- China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
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- Ai, Chao (författare)
- South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi,Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Zhejiang, Peoples R China
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- Zhao, Chao (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China;Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2020
- 2020
- Engelska.
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Ingår i: Carbohydrate Polymers. - : ELSEVIER SCI LTD. - 0144-8617 .- 1879-1344. ; 236
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of the present study is to characterize the structure of a novel natural polysaccharide from Agrocybe aegirita (AAPS) and evaluate its anti-aging activity. The MALLS and GC-MS analysis indicated that the AAPS with molecular weights of 1.81 x 10(4) Da was mainly composed by rhamnose, fucose, mannose, and glucose in a molar ratio of 2.90:10.25:3.70:38.27. The FT-IR and NMR analysis showed that the backbone of AAPS was alpha-L-Rhap-(1 -> 6)-beta-D-Glcp-(1 -> 2)-alpha-L-Fucp-(1 -> 6)-alpha-D-Glcp-(1 -> 5)-alpha-L-Araf-(1 -> 4)-beta-D-GlcpA-(1 -> 5)-alpha-L-Araf-(1 -> 6)-alpha-D-Manp-(1 -> 6)-alpha-D-Manp-(1 -> 2)-alpha-L-Fucp-(1 -> 6)-beta-D-Glap-(1 -> 2)-alpha-L-Rhap-(1 -> 6)-beta-D-Galp-(1 -> which linked with two side chains alpha-L-Fucp-(1 -> 6)-beta-D-Glcp-(1 -> 6)-beta-D-Manp-(1 -> and alpha-D-Xylp-(1 -> 2)-alpha-L-Fucp-(1 -> 5) -alpha-D-Araf-(1.6)-beta-D-Galp-(1 -> at O-H2 at H-4-arabinose and the terminal Galp residues, respectively. The MRC-5 cells induced by H2O2 were used to explore the anti-ageing effect and its underlying mechanism of AAPS. It showed a potent anti-ageing activity, representing by the increased cell viability and beta-Gal viability, prevented G1-phase cell-cycle arrest, and decreased mitochondrial membrane potential. The polysaccharides extracted from A. aegirita might be applied in functional food as anti-ageing ingredient.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Agrocybe aegirita polysaccharide
- Structure
- Anti-ageing
- Mitochondrial membrane potential
- Cell cycle
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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