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Monoamine oxidase A...
Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour
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- Checknita, Dave (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för neurovetenskap,Ctr Psychiat Res CPF, Dept Clin Neurosci, Norra Stn Gatan 69,7th Floor, S-11364 Stockholm, Sweden.
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- Bendre, Megha (författare)
- Uppsala universitet,Comasco: Neuropsykofarmakologi,Centrum för klinisk forskning, Västerås,Uppsala Univ, Uppsala Biomed Ctr, Dept Neurosci, Husargatan 3, S-75124 Uppsala, Sweden.;Uppsala Univ, Ctr Clin Res, Vastmanland Cty Council, Vastmanlands Sjukhus Vasteras, S-72189 Vasteras, Sweden.
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- Ekstrom, Tomas J. (författare)
- Karolinska Institutet
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Comasco: Neuropsykofarmakologi,Uppsala Univ, Uppsala Biomed Ctr, Dept Neurosci, Sci Life Lab, Husargatan 3, S-75124 Uppsala, Sweden.
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- Tiihonen, Jari (författare)
- Karolinska Institutet
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- Hodgins, Sheilagh (författare)
- Ctr Psychiat Res CPF, Dept Clin Neurosci, Norra Stn Gatan 69,7th Floor, S-11364 Stockholm, Sweden.;Univ Montreal, Inst Univ Sante Mentale Montreal, Dept Psychiat, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada.
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- Nilsson, Kent W. (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för neurovetenskap,Uppsala Univ, Uppsala Biomed Ctr, Dept Neurosci, Husargatan 3, S-75124 Uppsala, Sweden.;Uppsala Univ, Ctr Clin Res, Vastmanland Cty Council, Vastmanlands Sjukhus Vasteras, S-72189 Vasteras, Sweden.
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- Checknita, David (författare)
- Uppsala Univ, Uppsala Biomed Ctr, Dept Neurosci, Husargatan 3, S-75124 Uppsala, Sweden.;Ctr Psychiat Res CPF, Dept Clin Neurosci, Norra Stn Gatan 69,7th Floor, S-11364 Stockholm, Sweden.;Uppsala Univ, Ctr Clin Res, Vastmanland Cty Council, Vastmanlands Sjukhus Vasteras, S-72189 Vasteras, Sweden.
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(creator_code:org_t)
- ELSEVIER, 2020
- 2020
- Engelska.
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Ingår i: Behavioural Brain Research. - : ELSEVIER. - 0166-4328 .- 1872-7549. ; 382
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The association between childhood maltreatment and subsequent aggressive behaviour is modified by monoamine oxidase A (MAOA) functional polymorphism (MAOA-uVNTR) genotype, MAOA-Long (MAOA-L) in females, MAOA-Short (MAOA-S) in males. Childhood maltreatment is associated with differential DNA methylation in several genes. Consistent with recent proposals, we hypothesized that the association of the interaction of MAOA genotype and maltreatment with aggressive behaviour is further moderated by methylation of a region of interest (ROI) spanning the first exon and partial first intron of MAOA.Method: The sample included 117 women and 77 men who completed interviews and questionnaires to report maltreatment and aggressive behaviour towards others and provided saliva samples for DNA extraction. The MAOA-uVNTR polymorphism was genotyped, and methylation of the MAOA ROI was assessed.Results: Following adjustment for substance misuse, psychoactive medication use, and in males tobacco use, the highest levels of aggressive behaviour were found among maltreated male carriers of MAOA-S with high levels of exonic methylation.Conclusion: Methylation levels within the MAOA ROI further contributed to the interaction of MAOA risk genotypes and maltreatment on aggressive behaviours among men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- MAOA
- Methylation
- Genotype
- Maltreatment
- Aggression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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