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Positron emission t...
Positron emission tomography (O-15-water, C-11-acetate, C-11-HED) risk markers and nonsustained ventricular tachycardia in hypertrophic cardiomyopathy
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- Magnusson, Peter (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Dept Med, Cardiol Res Unit, Stockholm, Sweden.
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- Nordström, Jonny (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Radiologi
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- Harms, Hendrik J. (författare)
- Arhus Univ Hosp, Nucl Med, Aarhus, Denmark.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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- Gadler, Fredrik (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Cardiol Res Unit, Stockholm, Sweden.
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Arhus Univ Hosp, Nucl Med, Aarhus, Denmark.
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- Mörner, Stellan (författare)
- Umeå universitet,Kardiologi,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: IJC Heart & Vasculature. - : Elsevier BV. - 2352-9067. ; 26:26
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Background: The objectives of the study were to describe positron emission tomography (PET) parameters, using the tracers O-15-water at rest/stress, C-11-acetate, and C-11-HED, with regard to nonsustained ventricular tachycardia (NSVT) in hypertrophic cardiomyopathy (HCM). PET offers quantitative assessment of pathophysiology throughout the left ventricular segments, including the endocardium/epicardium. The potential use PET in risk stratification remains to be elucidated. NSVT provides a marker for sudden cardiac death.Methods: Patients with a validated diagnosis of HCM who had an implantable cardioverter-defibrillator were interrogated at 12 months and independently of PET-examinations.Results: In total, 25 patients (mean age 56.8 +/- 12.9 years, 76% males) were included and 10 reported NSVT. Mean myocardial blood flow (MBF) at rest was 0.91 ml/g/min and decreased at stress, 1.59 ml/ g/min. The mean gradient (endocardium/epicardium quotient) at rest was 1.14 +/- 0.09, while inverse at stress (mean 0.92 +/- 0.16). Notably, MBF gradient at stress was significantly lower in patients with NSVT (p = 0.022) and borderline at rest (p = 0.059) while global MBF at rest and stress were not. Mean myocardial oxygen consumption (MVO2) was 0.088 ml/g/min (higher in NSVT, p = 0.023) and myocardial external efficiency 18.5%. Using C-11-HED, the mean retention index was 0.11 min (1) and a higher volume of distribution (p = 0.089) or transmural gradient of clearance rate (p = 0.061) or lower clearance rate (p = 0.052) showed a tendency of association of NSVT.Conclusions: The endocardium/epicardium MBF gradient at stress is significantly lower in HCM patients with NSVT. This provides a novel approach to further refine risk stratification of sudden cardiac death.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Arrhythmia
- Hypertrophic cardiomyopathy
- Positron emission tomography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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