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Sökning: id:"swepub:oai:DiVA.org:uu-414318" > Neurotrophic Effect...

Neurotrophic Effects of Vascular Endothelial Growth Factor B and Novel Mimetic Peptides on Neurons from the Central Nervous System

Dmytriyeva, Oksana (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark.;Univ Copenhagen, Dept Biomed Sci, Fac Hlth & Med Sci, Lab Mol Pharmacol, DK-2200 Copenhagen, Denmark.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.
Ajenjo, Amaia de Diego (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark.
Lundo, Kathrine (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.
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Hertz, Henrik (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neuropsychiat, DK-2200 Copenhagen, Denmark.
Rasmussen, Kim K. (författare)
Univ Hosp Copenhagen, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, DK-2200 Copenhagen, Denmark.
Christiansen, Anders T. (författare)
Univ Hosp Copenhagen, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, DK-2200 Copenhagen, Denmark.
Klingelhofer, Jorg (författare)
Univ Hosp Copenhagen, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, DK-2200 Copenhagen, Denmark.
Nielsen, Alexander L. (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark.
Hoeber, Jan, 1986- (författare)
Uppsala universitet,Medicinsk genetik och genomik
Kozlova, Elena (författare)
Uppsala universitet,Kozlova: Regenerativ neurobiologi
Woldbye, David P. D. (författare)
Univ Hosp Copenhagen, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, DK-2200 Copenhagen, Denmark.
Pankratova, Stanislava (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark.;Univ Hosp Copenhagen, Bispebjerg Frederiksberg Hosp, Res Lab Stereol & Neurosci, DK-2200 Copenhagen, Denmark.
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Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark;Univ Copenhagen, Dept Biomed Sci, Fac Hlth & Med Sci, Lab Mol Pharmacol, DK-2200 Copenhagen, Denmark.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark. Univ Copenhagen, Fac Hlth & Med Sci, Dept Neurosci, Lab Neural Plast, DK-2200 Copenhagen, Denmark. (creator_code:org_t)
2020-04-13
2020
Engelska.
Ingår i: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 11:9, s. 1270-1282
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Vascular endothelial growth factor B (VEGFB) is a pleiotropic trophic factor, which in contrast to the closely related VEGFA is known to have a limited effect on angiogenesis. VEGFB improves survival in various tissues including the nervous system, where the effect was observed mainly for peripheral neurons. The neurotrophic effect of VEGFB on central nervous system neurons has been less investigated. Here we demonstrated that VEGFB promotes neurite outgrowth from primary cerebellar granule, hippocampal, and retinal neurons in vitro. VEGFB protected hippocampal and retinal neurons from both oxidative stress and glutamate-induced neuronal death. The VEGF receptor 1 (VEGFR1) is required for VEGFB-induced neurotrophic and neuroprotective effects. Using a structure-based approach, we designed short peptides, termed Vefin1-7, mimicking the binding interface of VEGFB to VEGFR1. Vefins were analyzed for their secondary structure and binding to VEGF receptors and compared with previously described peptides derived from VEGFA, another ligand of VEGFR1. We show that Vefins have neurotrophic and neuroprotective effects on primary hippocampal, cerebellar granule, and retinal neurons in vitro with potencies comparable to VEGFB. Similar to VEGFB, Vefins were not mitogenic for MCF-7 cancer cells. Furthermore, one of the peptides, Vefin7, even dose-dependently inhibited the proliferation of MCF-7 cells in vitro. Unraveling the neurotrophic and neuroprotective potentials of VEGFB, the only nonangiogenic factor of the VEGF family, is promising for the development of neuroprotective peptide-based therapies.

Ämnesord

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

Nyckelord

VEGFB
peptide
neurite outgrowth
neuronal survival

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