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Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

Thurner, Lorenz (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
Hartmann, Sylvia (author)
Goethe Univ, Dr Senckenberg Inst Pathol, Frankfurt, Germany.
Fadle, Natalie (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
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Regitz, Evi (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
Kemele, Maria (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
Kim, Yoo-Jin (author)
Saarland Univ, Inst Pathol, Med Sch, Homburg, Germany.
Bohle, Rainer Maria (author)
Saarland Univ, Inst Pathol, Med Sch, Homburg, Germany.
Nimmesgern, Anna (author)
Univ Saarland, Inst Med Microbiol & Hyg, Homburg, Germany.
von Mueller, Lutz (author)
Christophorus Kliniken, Inst Lab Med Microbiol & Hyg, German Natl Reference Ctr Clostridoides Clostridi, Coesfeld, Germany.
Kempf, Volkhard A. J. (author)
Goethe Univ, Univ Hosp, Inst Med Microbiol & Infect Control, Frankfurt, Germany.
Weniger, Marc A. (author)
Univ Duisburg Essen, Med Sch, Inst Cell Biol Canc Res, Essen, Germany.;Deutsch Konsortium Translat Krebsforsch DKTK, Heidelberg, Germany.
Neumann, Frank (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
Schneider, Nadine (author)
Univ Hosp Frankfurt Goethe Univ, Project Grp Translat Med & Pharmacol, Fraunhofer Inst Mol Biol & Appl Ecol IME, Frankfurt, Germany.;Univ Hosp Frankfurt Goethe Univ, Div Rheumatol, Frankfurt, Germany.
Vornanen, Martine (author)
Tampere Univ Hosp, Dept Pathol, Tampere 33520, Finland.;Univ Tampere, Tampere 33520, Finland.
Sundström, Christer (author)
Uppsala universitet,Klinisk och experimentell patologi
de Leval, Laurence (author)
Lausanne Univ Hosp, Inst Pathol, Lausanne, Switzerland.
Engert, Andreas (author)
Univ Cologne, Dept Internal Med 1, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldo, Cologne, Germany.;Univ Hosp Cologne, Dept Internal Med 1, German Hodgkin Study Grp, Cologne, Germany.
Eichenauer, Dennis A. (author)
Univ Cologne, Dept Internal Med 1, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldo, Cologne, Germany.;Univ Hosp Cologne, Dept Internal Med 1, German Hodgkin Study Grp, Cologne, Germany.
Kueppers, Ralf (author)
Univ Duisburg Essen, Med Sch, Inst Cell Biol Canc Res, Essen, Germany.;Deutsch Konsortium Translat Krebsforsch DKTK, Heidelberg, Germany.
Preuss, Klaus-Dieter (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
Hansmann, Martin-Leo (author)
Goethe Univ, Dr Senckenberg Inst Pathol, Frankfurt, Germany.;Frankfurt Inst Adv Studies, Frankfurt, Germany.
Pfreundschuh, Michael (author)
Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany.
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Saarland Univ, Med Sch, Jose Carreras Ctr Immuno & Gene Therapy & Interna, Homburg, Germany Goethe Univ, Dr Senckenberg Inst Pathol, Frankfurt, Germany. (creator_code:org_t)
2020-05-18
2020
English.
In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 11:1
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma of B-cell origin with frequent expression of functional B-cell receptors (BCRs). Here we report that expression cloning followed by antigen screening identifies DNA-directed RNA polymerase beta' (RpoC) from Moraxella catarrhalis as frequent antigen of BCRs of IgD(+) LP cells. Patients show predominance of HLA-DRB1*04/07 and the IgVH genes encode extraordinarily long CDR3s. High-titer, light-chain-restricted anti-RpoC IgG1/kappa -type serum-antibodies are additionally found in these patients. RpoC and MID/hag, a superantigen co-expressed by Moraxella catarrhalis that is known to activate IgD(+) B cells by binding to the Fc domain of IgD, have additive activation effects on the BCR, the NF-kappa B pathway and the proliferation of IgD(+) DEV cells expressing RpoC-specific BCRs. This suggests an additive antigenic and superantigenic stimulation of B cells with RpoC-specific IgD(+) BCRs under conditions of a permissive MHC-II haplotype as a model of NLPHL lymphomagenesis, implying future treatment strategies. Nodular lymphocyte-predominant Hodgkin lymphoma with IgD+ lymphocyte-predominant (LP) cells is a rare clinical distinct lymphoma subset of B-cell origin. Here the authors show that antigens expressed by Moraxella catarrhalis are recognized by B cell receptors of IgD+ LP cells, suggesting the contribution of chronic antigen stimulation to lymphomagenesis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

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