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Sulfadiazine Masque...
Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
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- Robertson, Luke P. (författare)
- Uppsala universitet,Växtekologi och evolution,Institutionen för farmaceutisk biovetenskap
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- Moodie, Lindon W. K. (författare)
- Uppsala universitet,Läkemedelsdesign och läkemedelsutveckling
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- Holland, Darren C. (författare)
- Griffith Univ, Environm Futures Res Inst, Gold Coast 4222, Australia;.
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- Jandér, K. Charlotte (författare)
- Uppsala universitet,Växtekologi och evolution
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- Göransson, Ulf, 1970- (författare)
- Uppsala universitet,Farmakognosi
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(creator_code:org_t)
- 2020-03-25
- 2020
- Engelska.
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Ingår i: Journal of Natural Products. - : AMER CHEMICAL SOC. - 0163-3864 .- 1520-6025. ; 83:4, s. 1305-1308
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://pubs.acs.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The structure of 2,4-(4'-aminobenzenamine)pyrimidine (1), a pyrimidine alkaloid previously isolated from the bulbs of Scilla madeirensis (Asparagaceae, synonym Autonoe madeirensis), has been revised. These conclusions were met via comparison of reported NMR and EIMS data with those obtained from synthetic standards. The corrected structure is the antibiotic sulfadiazine (2), which has likely been isolated as a contaminant from the site of collection. The reported bioactivity of 1 as an alpha(1)-adrenoceptor antagonist should instead be ascribed to sulfadiazine. Our findings appear to show another example of an anthropogenic contaminant being identified as a natural product and emphasize the importance of considering the biosynthetic origins of isolated compounds within a phylogenetic context.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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