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Association between...
Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men
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- Alsharari, Zayed (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Leander, Karin (författare)
- Karolinska Institutet
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- Sjögren, Per (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Carlsson, Axel (författare)
- Karolinska Institutet
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- Cederholm, Tommy (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- de Faire, Ulf (författare)
- Karolinska Institutet
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- Hellenius, Mai-Lis (författare)
- Karolinska Institutet
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- Marklund, Matti (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
- 2019-07-26
- 2020
- Engelska.
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6207 .- 1436-6215. ; 59:5, s. 2089-2097
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose Fatty acid composition in blood and adipose tissue (AT) is a useful biomarker of dietary fat quality. However, circulating saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have been proposed to also reflect carbohydrate-induced de novo lipogenesis (DNL) and stearoyl-CoA desaturase (SCD) activity. We aimed to test the hypothesis that high carbohydrate intake is related to SFA and MUFA in serum or AT in a Swedish population. Methods Fatty acid composition was measured in serum phospholipids (PL) and AT by gas chromatography in 63-year-old men (n = 299). Carbohydrate and alcohol intake was assessed (validated 7-day food records) in relation to total SFA, 16:0 (palmitate), 16:1 (palmitoleate), and estimated SCD activity (16:1n-7/16:0-ratio) in serum PL and in AT, respectively. Results Total carbohydrate intake was inversely associated with 16:0 in PL (P = 0.005), independently of BMI. Disaccharides were non-linearly (restricted cubic splines) and weakly associated with 16:1 and SCD activity in PL (nonlinear trend,P <= 0.02) but not AT. Carbohydrate intake and SCD expression were not associated (P >= 0.08,n = 81). Alcohol intake was, however, linearly associated with 16:0 in PL (P < 0.001), and with 16:1 (P < 0.001) and SCD activity (P <= 0.005) in both PL and AT. Conclusions Higher carbohydrate intake from sugar-rich foods or beverages was not clearly reflected by higher SFA or SCD activity in serum PL or AT. Alcohol was, however, associated with higher SFA and MUFA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Carbohydrate intake
- Fatty acid composition
- Saturated fatty acids
- De novo lipogenesis
- Stearoyl-Co A desaturase (SCD)
- Alcohol intake
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Alsharari, Zayed
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Leander, Karin
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Sjögren, Per
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Carlsson, Axel
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Cederholm, Tommy
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de Faire, Ulf
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visa fler...
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Hellenius, Mai-L ...
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Marklund, Matti
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Risérus, Ulf, 19 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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European Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet