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CD2 Immunobiology
CD2 Immunobiology
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- Binder, Christian (författare)
- Uppsala universitet,Klinisk immunologi,ITB Med AB, Res & Dev, Stockholm, Sweden.
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- Cvetkovski, Filip (författare)
- ITB Med AB, Res & Dev, Stockholm, Sweden.
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- Sellberg, Felix (författare)
- Uppsala universitet,Klinisk immunologi,ITB Med AB, Res & Dev, Stockholm, Sweden.
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- Berg, Stefan (författare)
- ITB Med AB, Res & Dev, Stockholm, Sweden.
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- Visbal, Horacio Paternina (författare)
- Uppsala universitet,Klinisk immunologi,ITB Med AB, Res & Dev, Stockholm, Sweden.
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- Sachs, David H. (författare)
- ITB Med AB, Res & Dev, Stockholm, Sweden.;Columbia Univ, Dept Med, Columbia Ctr Translat Immunol, Med Ctr, New York, NY USA.
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- Berglund, Erik (författare)
- Karolinska Institutet,ITB Med AB, Res & Dev, Stockholm, Sweden.;Karolinska Inst, Div Transplantat Surg, CLINTEC, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden.
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- Berglund, David, 1984- (författare)
- Uppsala universitet,Klinisk immunologi,ITB Med AB, Res & Dev, Stockholm, Sweden.
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(creator_code:org_t)
- 2020-06-09
- 2020
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 11
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effectsin vitroand clinical studies have proven the safety and efficacy of CD2-targeting biologics. Investigators have highlighted that the lack of attention to the CD2/LFA3 costimulatory pathway is amissed opportunity. Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- CD2
- CD58
- LFA-3 (lymphocyte functional antigen-3)
- T cell activation
- costimulation
- costimulation blockade
- Alefacept
- siplizumab
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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