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Clinicopathological...
Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
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- Gronroos, Toni (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Makinen, Artturi (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.
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- Laukkanen, Saara (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Mehtonen, Juha (författare)
- Univ Eastern Finland, Inst Biomed, Sch Med, Kuopio, Finland.
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- Nikkila, Atte (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Oksa, Laura (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Rounioja, Samuli (författare)
- Tampere Univ Hosp, Dept Hematol, Fimlab Labs, Tampere, Finland.
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- Marincevic-Zuniga, Yanara (författare)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Nordlund, Jessica (författare)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Pohjolainen, Virva (författare)
- Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.
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- Paavonen, Timo (författare)
- Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Dept Pathol, Tampere, Finland.
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Heinaniemi, Merja (författare)
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- Lohi, Olli (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pediat, Tampere, Finland.
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Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland. (creator_code:org_t)
- 2020-02-06
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gronroos, Toni
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Makinen, Artturi
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Laukkanen, Saara
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Mehtonen, Juha
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Nikkila, Atte
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Oksa, Laura
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visa fler...
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Rounioja, Samuli
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Marincevic-Zunig ...
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Nordlund, Jessic ...
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Pohjolainen, Vir ...
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Paavonen, Timo
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Heinaniemi, Merj ...
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Lohi, Olli
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Uppsala universitet