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Membrane-containing...
Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection
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- Azinas, Stavros (författare)
- Molecular recognition and host–pathogen interactions programme, CIC bioGUNE, CIBERehd, Derio, Spain; Biosurfaces Lab, CIC biomaGUNE, San Sebastian, Spain
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Bano, F. (författare)
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Torca, I. (författare)
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Bamford, D. H. (författare)
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Schwartz, G. A. (författare)
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Esnaola, J. (författare)
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Oksanen, H. M. (författare)
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Richter, R. P. (författare)
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Abrescia, N. G. (författare)
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 10:16, s. 7769-7779
- Relaterad länk:
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https://doi.org/10.1...
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https://pubs.rsc.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
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- art (ämneskategori)
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