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The impact of local...
The impact of local control in the treatment of children with advanced infantile and adult-type fibrosarcoma : Experience of the cooperative weichteilsarkom studiengruppe (CWS)
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- Sparber-Sauer, Monika (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
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- Vokuhl, Christian (författare)
- Kiel Pediat Tumor Registry, Sect Pediat Pathol, Dept Pathol, Kiel, Germany.
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- Seitz, Guido (författare)
- Univ Childrens Hosp Marburg, Dept Pediat Surg, Marburg, Germany.
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- Stegmaier, Sabine (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
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- Hallmen, Erika (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
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- von Kalle, Thekla (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Olgahosp,Inst Radiol, Stuttgart, Germany.
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- Scheer, Monika (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.
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- Muenter, Marc (författare)
- Klinikum Stuttgart, Inst Radiotherapy, Stuttgart, Germany.
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- Bielack, Stefan S. (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.;Univ Munster, Dept Pediat Hematol & Oncol, Munster, Germany.
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- Ladenstein, Ruth (författare)
- St Anna Childrens Hosp, Pediat Oncol, Vienna, Austria.
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- Niggli, Felix (författare)
- Univ Zurich, Dept Pediat Oncol, Zurich, Switzerland.
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- Ljungman, Gustaf, 1958- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Fuchs, Joerg (författare)
- Univ Childrens Hosp, Dept Pediat Surg & Urol, Tubingen, Germany.
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- Klingebiel, Thomas (författare)
- Goethe Univ, Univ Frankfurt, Dept Children & Adolescents, Frankfurt, Germany.
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- Koscielniak, Ewa (författare)
- Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany.;Goethe Univ, Univ Frankfurt, Dept Children & Adolescents, Frankfurt, Germany.
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Klinikum Stuttgart Olgahosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany Kiel Pediat Tumor Registry, Sect Pediat Pathol, Dept Pathol, Kiel, Germany. (creator_code:org_t)
- W B SAUNDERS CO-ELSEVIER INC, 2020
- 2020
- Engelska.
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Ingår i: Journal of Pediatric Surgery. - : W B SAUNDERS CO-ELSEVIER INC. - 0022-3468 .- 1531-5037. ; 55:9, s. 1740-1747
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and objectives: This study aims at examining the potential survival benefits of primary versus secondary surgery of children diagnosed with advanced infantile (iFS) and adult-type fibrosarcoma (aFS). Methods: Treatment and outcome of 89 children with FS treated within prospective Cooperative Studiengruppe (CWS) trials (1981-2016) were analyzed retrospectively. Results: Localized disease (LD) was diagnosed in 87 patients: 64/66 patients with iFS (<= 2 years) and 23 with aFS (>2 <= 18 years). Two patients (iFS) had metastatic disease. Resection was the mainstay of therapy of patients with LD resulting in microscopically complete (R0, IRS group I) (n = 29/87, 33%), microscopically incomplete (R1, IRS group II) (n = 17/87, 20%) and macroscopically incomplete (R2, IRS group III) (n = 41/87, 47%). Advanced LD (IRS group Ill) was present in 32/64 (50%) palieras with iFS and in 9/23 (39%) with aFS. Chemotherapy was added predominantly in patients with advanced disease and an assessable objective response to CHT was seen in 71% iFS and 75% aFS. The 5 -year event-free survival (EFS) of patients with iFS and aFS was 81% (+/- 10, 95% Cl) and 70% (+/- 19, 95% Cl) (p = 0.24); the 5 -year overall survival (OS) was 98% (+/- 3, 95% Cl) and 82% (+/- 16, 95% Cl) (p = 0.02). Primary resection was no prognostic factor. Secondary R0/R1 resection in patients with advanced disease improved 5-year EFS and OS in aFS (p = 0.002 and p = 0.000) but not in infants. Conclusions: Secondary resection improves outcome in advanced aFS but not in infants. Mutilating surgery in infants should be avoided. (C) 2019 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Fibrosarcoma
- Infantile
- Adult-type
- CWS group
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sparber-Sauer, M ...
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Vokuhl, Christia ...
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Seitz, Guido
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Stegmaier, Sabin ...
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Hallmen, Erika
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von Kalle, Thekl ...
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visa fler...
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Scheer, Monika
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Muenter, Marc
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Bielack, Stefan ...
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Ladenstein, Ruth
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Niggli, Felix
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Ljungman, Gustaf ...
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Fuchs, Joerg
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Klingebiel, Thom ...
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Koscielniak, Ewa
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- MEDICIN OCH HÄLSOVETENSKAP
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Uppsala universitet