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Population Toxicoki...
Population Toxicokinetic Modeling of Cadmium for Health Risk Assessment
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- Amzal, Billy (författare)
- European Food Safety Author, Assessment Methodol Unit, I-43100 Parma, Italy.
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- Julin, Bettina (författare)
- Karolinska Institutet
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- Vahter, Marie (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Johanson, Gunnar (författare)
- Karolinska Institutet
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- Akesson, Agneta (författare)
- Karolinska Institutet
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Karolinska Institutet European Food Safety Author, Assessment Methodol Unit, I-43100 Parma, Italy (creator_code:org_t)
- US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2009
- 2009
- Engelska.
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Ingår i: Journal of Environmental Health Perspectives. - : US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE. - 0091-6765 .- 1552-9924. ; 117:8, s. 1293-1301
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: Cadmium is a widespread environmental pollutant that has been shown to exert toxic effects on kidney and bones in humans after long-term exposure. Urinary cadmium concentration is considered a good biomarker of accumulated cadmium in kidney, and diet is the main source of cadmium among nonsmokers. OBJECTIVE: Modeling the link between urinary cadmium and dietary cadmium intake is a key step in the risk assessment of long-term cadmium exposure. There is, however, little knowledge on how this link may vary, especially for susceptible population strata. METHODS: We used a large population-based study (the Swedish Mammography Cohort), with repeated dietary intake data covering a period of 20 years, to compare estimated dietary cadmium intake with urinary cadmium concentrations on an individual basis. A modified version of the Nordberg-Kjellstrom model and a one-compartment model were evaluated in terms of their predictions of urinary cadmium. We integrated the models and quantified the between-person variability of cadmium half-life in the population. Finally, sensitivity analyses and Monte Carlo simulations were performed to illustrate how the latter model could serve as a robust tool supporting the risk assessment of cadmium in humans. RESULTS: The one-compartment population model appeared to be an adequate modeling option to link cadmium intake to urinary cadmium and to describe the population variability. We estimated the cadmium half-life to be about 11.6 years, with about 25% population variability. CONCLUSIONS: Population toxicokinetic models can be robust and useful tools for risk assessment of chemicals, because they allow quantification and integration of population variability in toxicokinetics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- alternative model development
- Bayesian inference
- cadmium toxicokinetics
- population variability
- risk assessment
- toxicokinetic models
- urinary cadmium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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