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Diabetes mellitus a...
Diabetes mellitus and risk of endometrial cancer : a meta-analysis
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- Friberg, E. (författare)
- Karolinska Institutet
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- Orsini, N. (författare)
- Karolinska Institutet
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Mantzoros, C. S. (författare)
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- Wolk, A. (författare)
- Karolinska Institutet
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visa färre...
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(creator_code:org_t)
- 2007-05-03
- 2007
- Engelska.
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Ingår i: Diabetologia. - Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, S-17177 Stockholm, Sweden. Harvard Univ, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Cambridge, MA 02138 USA. : SPRINGER. - 0012-186X .- 1432-0428. ; 50:7, s. 1365-1374
- Relaterad länk:
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies. Subjects and methods We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model. Results The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29). Conclusions/interpretation Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- case-control
- cohort
- diabetes
- endometrial cancer
- meta-analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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