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Dairy products and pancreatic cancer risk : a pooled analysis of 14 cohort studies

Genkinger, J. M. (författare)
Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
Wang, M. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
Li, R. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
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Albanes, D. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
Anderson, K. E. (författare)
Univ Minnesota, Sch Publ Hlth, Mason Canc Ctr, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
Bernstein, L. (författare)
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA.;City Hope Natl Med Ctr, Duarte, CA 91010 USA.
van den Brandt, P. A. (författare)
Maastricht Univ, Sch Oncol & Dev Biol GROW, Dept Epidemiol, Maastricht, Netherlands.
English, D. R. (författare)
Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Canc Epidemiol Ctr,Canc Council Victoria, Melbourne, Vic, Australia.
Freudenheim, J. L. (författare)
SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
Fuchs, C. S. (författare)
Dana Farber Canc Inst, Div Med Oncol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
Gapstur, S. M. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Giles, G. G. (författare)
Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Canc Epidemiol Ctr,Canc Council Victoria, Melbourne, Vic, Australia.
Goldbohm, R. A. (författare)
TNO Qual Life, Dept Prevent & Hlth, Leiden, Netherlands.
Hakansson, N. (författare)
Karolinska Institutet
Horn-Ross, P. L. (författare)
Canc Prevent Inst Calif, Fremont, CA USA.
Koushik, A. (författare)
Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada.
Marshall, J. R. (författare)
SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
McCullough, M. L. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Miller, A. B. (författare)
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
Robien, K. (författare)
George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Epidemiol & Biostat, Washington, DC USA.
Rohan, T. E. (författare)
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
Schairer, C. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
Silverman, D. T. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
Stolzenberg-Solomon, R. Z. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
Virtamo, J. (författare)
Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
Willett, W. C. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
Wolk, A. (författare)
Karolinska Institutet
Ziegler, R. G. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
Smith-Warner, S. A. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. (creator_code:org_t)
OXFORD UNIV PRESS, 2014
2014
Engelska.
Ingår i: Annals of Oncology. - : OXFORD UNIV PRESS. - 0923-7534 .- 1569-8041. ; 25:6, s. 1106-1115
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • .Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in pancreatic carcinogenesis. In this pooled analysis of the primary data from 14 prospective cohort studies, 2212 incident pancreatic cancer cases were identified during follow-up among 862 680 individuals. Adjusting for smoking habits, personal history of diabetes, alcohol intake, body mass index (BMI), and energy intake, multivariable study-specific hazard ratios (MVHR) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazards models and then pooled using a random effects model. There was no association between total milk intake and pancreatic cancer risk (MVHR = 0.98, 95% CI = 0.82-1.18 comparing a parts per thousand yen500 with 1-69.9 g/day). Similarly, intakes of low-fat milk, whole milk, cheese, cottage cheese, yogurt, and ice-cream were not associated with pancreatic cancer risk. No statistically significant association was observed between dietary (MVHR = 0.96, 95% CI = 0.77-1.19) and total calcium (MVHR = 0.89, 95% CI = 0.71-1.12) intake and pancreatic cancer risk overall when comparing intakes a parts per thousand yen1300 with < 500 mg/day. In addition, null associations were observed for dietary and total vitamin D intake and pancreatic cancer risk. Findings were consistent within sex, smoking status, and BMI strata or when the case definition was limited to pancreatic adenocarcinoma. Overall, these findings do not support the hypothesis that consumption of dairy foods, calcium, or vitamin D during adulthood is associated with pancreatic cancer risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

pancreatic cancer
dairy products
calcium intake
pooled analysis

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